Note: This document contains side effect information about morphine liposomal. Some dosage forms listed on this page may not apply to the brand name DepoDur.

Applies to morphine liposomal: injectable suspension extended release.

General

The more commonly reported side effects have included nausea, pruritus, pyrexia, vomiting, hypotension, anemia, headache, constipation, decreased oxygen saturation, urinary retention, and dizziness.^[Ref]

Respiratory

Very common (10% or more): Decreased oxygen saturation

Common (1% to 10%): Hypoxia, respiratory depression, hypercapnia, dyspnea

Postmarketing reports: Severe respiratory depression, involving apnea or respiratory arrest, and cardiac arrest^[Ref]

Prolonged and serious respiratory depression was reported when administration was associated with subarachnoid puncture. In these cases, respiratory depression occurred following apparent recovery from anesthesia (within 12 hours of administration).

Four percent of patients receiving this drug in clinical trials required treatment with narcotic antagonists for respiratory depression; 90% of respiratory depression events were reported within the first 24 hours. Delayed respiratory depression (occurring up to 48 hours postdose) was reported in 2% of patients; 0.6% of patients reported respiratory depression after more than 48 hours. During the postmarketing period, severe respiratory depression involving apnea or respiratory arrest have been reported following administration of labeled doses.^[Ref]

Nervous system

Postmarketing reports: Central nervous system depression, including obtunded feeling, non-arousable condition, unresponsiveness, confusion, and lethargy^[Ref]

CNS depression, including obtunded feeling, non-arousable condition, unresponsiveness, confusion, and lethargy, has been reported. In most cases, there was concomitant administration of different narcotics or hypnotic/sedative medications in the post-operative period.^[Ref]

Cardiovascular

Very common (10% or more): Hypotension

Common (1% to 10%): Tachycardia, hypertension, bradycardia^[Ref]

Gastrointestinal

Very common (10% or more): Vomiting, constipation, nausea

Common (1% to 10%): Flatulence, paralytic ileus, dyspepsia, abdominal distension^[Ref]

Dermatologic

Very common (10% or more): Pruritus

Common (1% to 10%): Hypoesthesia, increased sweating^[Ref]

Musculoskeletal

Common (1% to 10%): Rigors^[Ref]

Metabolic

Common (1% to 10%): Hypokalemia

Psychiatric

Common (1% to 10%): Anxiety

Hematologic

Very common (10% or more): Anemia

Common (1% to 10%): Decreased hematocrit^[Ref]

Genitourinary

Very common (10% or more): Urinary retention

Common (1% to 10%): Bladder spasm, oliguria^[Ref]