Usual Adult Dose for Benign Prostatic Hyperplasia

Extended-release tablet: 10 mg orally once a day immediately after the same meal each day

Renal Dose Adjustments

Severe renal insufficiency: Caution is advised

Liver Dose Adjustments

Severe hepatic insufficiency: Contraindicated

Precautions

This drug is not recommended for use in children.

Consult WARNINGS section for additional precautions.

Dialysis

Alfuzosin is not significantly dialyzable.

Other Comments

Patient advice:

• Patients (especially those receiving antihypertensive medications), should be counseled on the possibility of orthostatic hypotension with or without symptoms occurring within a few hours following administration. The patient should be advised to lie down until the symptoms have disappeared. These effects are usually transient, occur at the beginning of treatment, and do not generally affect continuation of treatment.
• Patients should be advised that side effects including vertigo, dizziness, and asthenia may occur primarily at the beginning of treatment and may affect their ability to drive vehicles or operate machinery. They should not undertake such activities until they know how alfuzosin affects them.
• Tablets should not be chewed or crushed.
• Patients with hereditary problems of galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption should not take this medicine.
• Alfuzosin should be administered after the same meal each day.