Antimalarial quinolines
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Arakoda Dosage

Drug Detail:Arakoda (Tafenoquine [ ta-fen-o-kwin ])

Generic Name: TAFENOQUINE 100mg

Dosage Form: tablet, film coated

Drug Class: Antimalarial quinolines

Contents
Uses Warnings Before Taking Dosage Side effects Interactions

Tests to be Performed Prior to ARAKODA Dose Initiation

All patients must be tested for glucose-6-phosphate dehydrogenase (G6PD) deficiency prior to prescribing ARAKODA [see Contraindications (4), Warnings and Precautions (5.1)].

Pregnancy testing is recommended for females of reproductive potential prior to initiating treatment with ARAKODA [see Use in Specific Populations (8.1 and 8.3)].

Recommended Dosage and Administration Instructions

The recommended dosage of ARAKODA is described in Table 1 below. ARAKODA can be administered for up to 6 months of continuous dosing.

Table 1: Recommended Dosage of ARAKODA in Patients (18 Years of Age and Older)

Regimen Name

Timing

Dosage

Loading regimen

For each of the 3 days before travel to a malarious area

200 mg (2 of the 100 mg tablets) once daily for 3 days

Maintenance regimen

While in the malarious area

200 mg (2 of the 100 mg tablets) once weekly – start 7 days after the last loading regimen dose

Terminal prophylaxis regimen

In the week following exit from the malarious area

200 mg (2 of the 100 mg tablets) taken one time, 7 days after the last maintenance dose
•
Administer ARAKODA with food. [see Clinical Pharmacology (12.3)].
•
Swallow the tablet whole. Do not break, crush or chew the tablets.
•
Complete the full course of ARAKODA including the loading dose and the terminal dose.
Table 2: How to Replace Missed Doses of ARAKODA

Dose(s) Missed

How to Replace Missed Dose(s):

1 Loading dose

1 dose of 200 mg (2 of the 100 mg tablets) so that a total of 3 daily loading doses have been taken. Begin maintenance dose 1 week after the last loading dose.

2 Loading doses

2 doses of 200 mg (2 of the 100 mg tablets) on 2 consecutive days so that a total of 3 daily loading doses have been taken. Begin maintenance dose 1 week after the last loading dose.

1 Maintenance (weekly) dose

1 dose of 200 mg (2 of the 100 mg tablets) on any day up to the time of the next scheduled weekly dose.

2 Maintenance (weekly) doses

1 dose of 200 mg (2 of the 100 mg tablets) on any day up to the time of the next scheduled weekly dose.

3 or more Maintenance (weekly) doses

2 doses of 200 mg (2 of the 100 mg tablets), taken as 200 mg (2 of the 100 mg tablets) once daily for 2 days up to the time of the next weekly dose.

Terminal prophylaxis dose

1 dose of 200 mg (2 of the 100 mg tablets) as soon as remembered.
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