Drug Class: Anticholinergics / antispasmodics
Usual Adult Dose for Duodenal Ulcer
Elixir: 1 or 2 teaspoonfuls orally 3 or 4 times a day according to severity of symptoms
Regular Release Tablets: 1 or 2 tablets orally 3 or 4 times a day according to severity of symptoms
Extended release tablets: 1 tablet orally every 12 hours
- If indicated, 1 tablet orally every 8 hours
Comments:
- Adjust dose to patient needs to assure symptomatic control with minimum adverse effects.
Usual Adult Dose for Irritable Bowel Syndrome
Elixir: 1 or 2 teaspoonfuls orally 3 or 4 times a day according to severity of symptoms
Regular Release Tablets: 1 or 2 tablets orally 3 or 4 times a day according to severity of symptoms
Extended release tablets: 1 tablet orally every 12 hours
- If indicated, 1 tablet orally every 8 hours
Comments:
- Adjust dose to patient needs to assure symptomatic control with minimum adverse effects.
Usual Adult Dose for Enterocolitis
Elixir: 1 or 2 teaspoonfuls orally 3 or 4 times a day according to severity of symptoms
Regular Release Tablets: 1 or 2 tablets orally 3 or 4 times a day according to severity of symptoms
Extended release tablets: 1 tablet orally every 12 hours
- If indicated, 1 tablet orally every 8 hours
Comments:
- Adjust dose to patient needs to assure symptomatic control with minimum adverse effects.
Usual Pediatric Dose for Duodenal Ulcer
Elixir:
Initial oral dose by weight:
4.5 kg: 0.5 mL every 4 hours OR 0.75 mL every 6 hours
9.1 kg: 1 mL every 4 hours OR 1.5 mL every 6 hours
13.6 kg: 1.5 mL every 4 hours OR 2 mL every 6 hours
22.7 kg: 2.5 mL every 4 hours OR 3.75 mL every 6 hours
34 kg: 3.75 mL every 4 hours OR 5 mL every 6 hours
45.4 kg: 5 mL every 4 hours OR 7.5 mL every 6 hours
Comments:
- Adjust dose to patient needs to assure symptomatic control with minimum adverse effects.
- Use a pediatric dosing device or oral syringe to measure the dose.
Usual Pediatric Dose for Irritable Bowel Syndrome
Elixir:
Initial oral dose by weight:
4.5 kg: 0.5 mL every 4 hours OR 0.75 mL every 6 hours
9.1 kg: 1 mL every 4 hours OR 1.5 mL every 6 hours
13.6 kg: 1.5 mL every 4 hours OR 2 mL every 6 hours
22.7 kg: 2.5 mL every 4 hours OR 3.75 mL every 6 hours
34 kg: 3.75 mL every 4 hours OR 5 mL every 6 hours
45.4 kg: 5 mL every 4 hours OR 7.5 mL every 6 hours
Comments:
- Adjust dose to patient needs to assure symptomatic control with minimum adverse effects.
- Use a pediatric dosing device or oral syringe to measure the dose.
Usual Pediatric Dose for Enterocolitis
Elixir:
Initial oral dose by weight:
4.5 kg: 0.5 mL every 4 hours OR 0.75 mL every 6 hours
9.1 kg: 1 mL every 4 hours OR 1.5 mL every 6 hours
13.6 kg: 1.5 mL every 4 hours OR 2 mL every 6 hours
22.7 kg: 2.5 mL every 4 hours OR 3.75 mL every 6 hours
34 kg: 3.75 mL every 4 hours OR 5 mL every 6 hours
45.4 kg: 5 mL every 4 hours OR 7.5 mL every 6 hours
Comments:
- Adjust dose to patient needs to assure symptomatic control with minimum adverse effects.
- Use a pediatric dosing device or oral syringe to measure the dose.
Renal Dose Adjustments
Use with caution.
Liver Dose Adjustments
Use with caution.
- Barbiturates are hepatically metabolized, so initial doses should be small in patients with hepatic dysfunction.
Dialysis
Data not available
Other Comments
General:
- Atropine/hyoscyamine/phenobarbital/scopolamine has been classified as "possibly" effective by the FDA for use as adjunctive therapy in the treatment of irritable bowel syndrome (irritable colon, spastic colon, mucous colitis) and acute enterocolitis.
- It has not been shown conclusively whether anticholinergic/antispasmodic drugs aid in the healing of duodenal ulcer, decrease the rate of recurrences, or prevent complications.
Patient advice:
- Instruct patients not to increase their dose of this drug without consulting their physician.
- Instruct patients not to share this drug with others.
- This drug has a risk of physical and/or psychological dependence.
- This drug may impair mental and/or physical abilities needed for potentially hazardous tasks such as driving or operating machinery.
- Use of alcohol with this drug may cause additional central nervous system depressant effects.
- This drug may increase the risk of heatstroke because it decreases sweating.
- Avoid becoming overheated in hot weather, saunas, and during exercise or other strenuous activities.
- Patients should tell their healthcare provider if they take antihistamines, anti-seizure medications, medications for sleep or anxiety, narcotic pain relievers, or psychiatric medications.
