Acute Coronary Syndrome or a History of Myocardial Infarction

Initiate treatment with a 180 mg loading dose of BRILINTA. Administer 90 mg of BRILINTA twice daily during the first year after an ACS event. After one year, administer 60 mg of BRILINTA twice daily.

Use BRILINTA with a daily maintenance dose of aspirin of 75 to 100 mg [see Warnings and Precautions (5.2) and Clinical Studies (14)].

Coronary Artery Disease but No Prior Stroke or Myocardial Infarction

Administer 60 mg of BRILINTA twice daily. For all patients with ACS [see Dosage and Administration (2.1)].

Use BRILINTA with a daily maintenance dose of aspirin of 75 to 100 mg [see Warnings and Precautions (5.2) and Clinical Studies (14)].

Acute Ischemic Stroke or Transient Ischemic Attack (TIA)

Initiate treatment with a 180 mg loading dose of BRILINTA and then continue with 90 mg twice daily for up to 30 days. The treatment effect accrued early in the course of therapy [see Clinical Studies (14.3)].

Use BRILINTA with a loading dose of aspirin (300 to 325 mg) and a daily maintenance dose of aspirin of 75 to 100 mg [see Warnings and Precautions (5.2) and Clinical Studies (14)].

Administration

A patient who misses a dose of BRILINTA should take one tablet (their next dose) at its scheduled time.

For patients who are unable to swallow tablets whole, BRILINTA tablets can be crushed, mixed with water and drunk. The mixture can also be administered via a nasogastric tube (CH8 or greater) [see Clinical Pharmacology (12.3)].

Do not administer BRILINTA with another oral P2Y12 platelet inhibitor.