Usual Adult Dose for Intraocular Hypertension

One drop in the affected eye(s) three times a day

Comments:

• If more than one topical ophthalmic drug is being used, the drugs should be administered at least 10 minutes apart.

Usual Adult Dose for Glaucoma (Open Angle)

One drop in the affected eye(s) three times a day

Comments:

• If more than one topical ophthalmic drug is being used, the drugs should be administered at least 10 minutes apart.

Renal Dose Adjustments

Severe renal impairment (CrCl less than 30 mL/min): Not recommended

Liver Dose Adjustments

Hepatic impairment: Data not available

Precautions

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Patient advice:

• To minimize systemic absorption, pressure should be applied to the tear duct for two minutes immediately after administration.
• Patients should be instructed to avoid allowing the tip of the container to contact the eye, eyelid, fingers or any other surface.

• Store at 4 C to 30 C (39 F to 86 F)
• Shake well before use.
• Discard container 4 weeks after opening.