Usual Adult Dose for Cough and Nasal Congestion

Brompheniramine/dextromethorphan/PSE 3 mg-15 mg-30 mg/5 mL oral syrup:
5 to 10 mL every 4 to 6 hours not to exceed 4 doses daily.

Brompheniramine/dextromethorphan/PSE 3 mg-30 mg-50 mg/5 mL oral syrup:
5 mL every 6 hours not to exceed 4 doses daily.

Brompheniramine/dextromethorphan/PSE 4 mg-20 mg-20 mg/5 mL oral liquid:
5 to 10 mL every 4 to 6 hours not to exceed 4 doses daily.

Brompheniramine/dextromethorphan/PSE 4 mg-20 mg-40 mg oral tablet:
1 tablet orally every 4 to 6 hours not to exceed 6 tablets daily.

Brompheniramine/dextromethorphan/PSE 8 mg-60 mg-90 mg/5 mL oral suspension, extended release:
5 mL orally every 12 hours not to exceed 2 doses daily.

Usual Pediatric Dose for Cough and Nasal Congestion

Brompheniramine/dextromethorphan/PSE 1 mg-3 mg-12.5 mg/mL oral liquid
1 to 3 months: 0.125 to 0.25 mL orally 4 times daily.
4 to 6 months: 0.25 to 0.5 mL orally 4 times daily.
7 to 11 months: 0.375 to 0.75 mL orally 4 times daily.
12 to 24 months: 0.5 to 1 mL orally 4 times daily.

Brompheniramine/dextromethorphan/PSE 1 mg-5 mg-12 mg/mL oral liquid
2 to 5 years: 1 mL orally every 4 to 6 hours.
6 to 12 years: 2 mL orally every 4 to 6 hours.

Brompheniramine/dextromethorphan/PSE 3 mg-15 mg-30 mg/5 mL oral syrup:
2 to 5 years: 1.25 to 2.5 mL every 4 to 6 hours not to exceed 4 doses daily.
6 to 11 years: 2.5 to 5 mL every 4 to 6 hours not to exceed 4 doses daily.
12 years or older: 5 to 10 mL every 4 to 6 hours not to exceed 4 doses daily.

Brompheniramine/dextromethorphan/PSE 3 mg-30 mg-50 mg/5 mL oral syrup:
6 to 11 years: 2.5 mL every 6 hours not to exceed 4 doses daily
12 years or older: 5 mL every 6 hours not to exceed 4 doses daily.

Brompheniramine/dextromethorphan/PSE 4 mg-20 mg-20 mg/5 mL oral liquid:
2 to 5 years: 2.5 mL every 4 to 6 hours not to exceed 4 doses daily.
6 to 11 years: 5 mL every 4 to 6 hours not to exceed 4 doses daily.
12 years or older: 5 to 10 mL every 4 to 6 hours not to exceed 4 doses daily.

Brompheniramine/dextromethorphan/PSE 4 mg-20 mg-40 mg oral tablet:
6 to 11 years: 1/2 tablet orally every 4 to 6 hours not to exceed 3 tablets daily.
12 years or older: 1 tablet orally every 4 to 6 hours not to exceed 6 tablets daily.

Brompheniramine/dextromethorphan/PSE 8 mg-60 mg-90 mg/5 mL oral suspension, extended release:
2 to 5 years: 1.25 mL orally every 12 hours not to exceed 2 doses daily.
6 to 11 years: 2.5 mL orally every 12 hours not to exceed 2 doses daily.
12 years or older: 5 mL orally every 12 hours not to exceed 2 doses daily.

Renal Dose Adjustments

Data not available.

Liver Dose Adjustments

Data not available.

Precautions

The FDA has not approved use of over-the-counter cough and cold medications to children aged less than 2 years, and proper dosing for children in this age group has not been studied. Clinicians should be aware of the risk for serious illness or fatal overdose from administration of cough and cold medications to children aged less than 2 years. Clinicians should be certain that caregivers understand 1) the importance of administering cough and cold medications only as directed and 2) the risk for overdose if they administer additional medications that might contain the same ingredient.

Dialysis

Data not available.