Usual Adult Dose for Allergic Rhinitis

Tablet (carbinoxamine maleate 4 mg): 1 tablet orally daily as needed; may increase dosage as needed up to a maximum of 24 mg/day in divided doses every 6 to 8 hours

Tablet, timed-release (carbinoxamine maleate 8 mg): 1 tablet orally every 12 hours

Capsule, extended-release (carbinoxamine maleate 2 mg/8 mg): 1 capsule orally every 12 hours, not to exceed 2 capsules in a 24-hour period

Solution (carbinoxamine maleate 4 mg/5 mL): 5 mL orally daily as needed; may increase dosage as needed up to a maximum of 24 mg/day in divided doses every 6 to 8 hours

Suspension (carbinoxamine maleate-tannate 2 mg-6 mg/5 mL): 5 mL orally every 12 hours

Liquid (carbinoxamine maleate 4 mg/5 mL): 5 mL orally 4 times a day

Liquid (carbinoxamine maleate 1.5 mg/5 mL): 10 mL orally 4 times a day

Extended release suspension (carbinoxamine tannate 3.6 mg/5 mL): 10 to 20 mL orally every 12 hours

Liquid (carbinoxamine maleate 1.75 mg/5 mL): 10 mL orally 4 times a day

Usual Adult Dose for Allergic Urticaria

Tablet (carbinoxamine maleate 4 mg): 1 tablet orally daily as needed; may increase dosage as needed up to a maximum of 24 mg/day in divided doses every 6 to 8 hours

Capsule, extended-release (carbinoxamine maleate 2 mg/8 mg): 1 capsule orally every 12 hours, not to exceed 2 capsules in a 24-hour period

Solution (carbinoxamine maleate 4 mg/5 mL): 5 mL orally daily as needed; may increase dosage as needed up to a maximum of 24 mg/day in divided doses every 6 to 8 hours

Suspension (carbinoxamine maleate-tannate 2 mg-6 mg/5 mL): 5 mL orally every 12 hours

Usual Adult Dose for Allergic Reaction

Tablet (carbinoxamine maleate 4 mg): 1 tablet orally daily as needed; may increase dosage as needed up to a maximum of 24 mg/day in divided doses every 6 to 8 hours

Solution (carbinoxamine maleate 4 mg/5 mL): 5 mL orally daily as needed; may increase dosage as needed up to a maximum of 24 mg/day in divided doses every 6 to 8 hours

Usual Adult Dose for Allergic Conjunctivitis

Tablet (carbinoxamine maleate 4 mg): 1 tablet orally daily as needed; may increase dosage as needed up to a maximum of 24 mg/day in divided doses every 6 to 8 hours

Solution (carbinoxamine maleate 4 mg/5 mL): 5 mL orally daily as needed; may increase dosage as needed up to a maximum of 24 mg/day in divided doses every 6 to 8 hours

Usual Adult Dose for Dermatographism

Tablet (carbinoxamine maleate 4 mg): 1 tablet orally daily as needed; may increase dosage as needed up to a maximum of 24 mg/day in divided doses every 6 to 8 hours

Solution (carbinoxamine maleate 4 mg/5 mL): 5 mL orally daily as needed; may increase dosage as needed up to a maximum of 24 mg/day in divided doses every 6 to 8 hours

Usual Adult Dose for Vasomotor Rhinitis

Tablet (carbinoxamine maleate 4 mg): 1 tablet orally daily as needed; may increase dosage as needed up to a maximum of 24 mg/day in divided doses every 6 to 8 hours

Solution (carbinoxamine maleate 4 mg/5 mL): 5 mL orally daily as needed; may increase dosage as needed up to a maximum of 24 mg/day in divided doses every 6 to 8 hours

Usual Pediatric Dose for Allergic Rhinitis

Liquid (carbinoxamine maleate 1.75 mg/5 mL):
Liquid (carbinoxamine maleate 1.5 mg/5 mL):
<2 years: Safety and effectiveness unknown
2 years to 6 years: 5 mL orally 4 times a day
>=6 years: 10 mL orally 4 times a day

Liquid (carbinoxamine maleate 4 mg/5 mL):
Suspension (carbinoxamine maleate-tannate 2 mg-6 mg/5 mL):
<2 years: Safety and effectiveness unknown
2 years to 6 years: 2.5 mL orally 4 times a day
>=6 years: 5 mL orally 4 times a day

Solution (carbinoxamine maleate 4 mg/5 mL):
<2 years: Safety and effectiveness unknown
2 years to 6 years: 2.5 mL orally daily as needed; may increase dosage as needed, approximately 0.2 to 0.4 mg/kg/day in divided doses every 6 to 8 hours
>=6 years: 5 mL orally daily as needed; may increase dosage as needed up to a maximum of 24 mg/day in divided doses every 6 to 8 hours

Tablet (carbinoxamine maleate 4 mg):
<2 years: Safety and effectiveness unknown
2 to 6 years: 1/2 tablet orally daily as needed; may increase dosage as needed, approximately 0.2 to 0.4 mg/kg/day in divided doses every 6 to 8 hours
>=6 years: 1 tablet orally daily as needed; may increase dosage as needed up to a maximum of 24 mg/day in divided doses every 6 to 8 hours

Tablet, timed-release (carbinoxamine maleate 8 mg):
6 to 12 years: 1/2 tablet orally every 12 hours
>=12 years: 1 tablet orally every 12 hours

Capsule, extended-release (carbinoxamine maleate 2 mg/8 mg):
>=12 years: 1 capsule orally every 12 hours, not to exceed 2 capsules in a 24-hour period

Extended release suspension (carbinoxamine tannate 3.6 mg/5 mL):
2 years to 6 years: 2.5 to 5 mL orally every 12 hours
6 years to 12 years: 5 to 10 mL orally every 12 hours
12 years to 18 years: 10 to 20 mL orally every 12 hours

Usual Pediatric Dose for Allergic Urticaria

Suspension (carbinoxamine maleate-tannate 2 mg-6 mg/5 mL):
<2 years: Safety and effectiveness unknown
2 years to 6 years: 2.5 mL orally every 12 hours
>=6 years: 5 mL orally every 12 hours

Solution (carbinoxamine maleate 4 mg/5 mL):
<2 years: Safety and effectiveness unknown
2 years to 6 years: 2.5 mL orally daily as needed; may increase dosage as needed, approximately 0.2 to 0.4 mg/kg/day in divided doses every 6 to 8 hours
>=6 years: 5 mL orally daily as needed; may increase dosage as needed up to a maximum of 24 mg/day in divided doses every 6 to 8 hours

Tablet (carbinoxamine maleate 4 mg):
<2 years: Safety and effectiveness unknown
2 years to 6 years: 1/2 tablet orally daily as needed; may increase dosage as needed, approximately 0.2 to 0.4 mg/kg/day in divided doses every 6 to 8 hours
>=6 years: 1 tablet orally daily as needed; may increase dosage as needed up to a maximum of 24 mg/day in divided doses every 6 to 8 hours

Capsule, extended-release (carbinoxamine maleate 2 mg/8 mg):
>=12 years: 1 capsule orally every 12 hours, not to exceed 2 capsules per day

Usual Pediatric Dose for Allergic Reaction

Solution (carbinoxamine maleate 4 mg/5 mL):
<2 years: Safety and effectiveness unknown
2 years to 6 years: 2.5 mL orally daily as needed; may increase dosage as needed, approximately 0.2 to 0.4 mg/kg/day in divided doses every 6 to 8 hours
>=6 years: 5 mL orally daily as needed; may increase dosage as needed up to a maximum of 24 mg/day in divided doses every 6 to 8 hours

Tablet (carbinoxamine maleate 4 mg):
<2 years: Safety and effectiveness unknown
2 to 6 years: 1/2 tablet orally daily as needed; may increase dosage as needed, approximately 0.2 to 0.4 mg/kg/day in divided doses every 6 to 8 hours
>=6 years: 1 tablet orally daily as needed; may increase dosage as needed up to a maximum of 24 mg/day in divided doses every 6 to 8 hours

Usual Pediatric Dose for Allergic Conjunctivitis

Solution (carbinoxamine maleate 4 mg/5 mL):
<2 years: Safety and effectiveness unknown
2 years to 6 years: 2.5 mL orally daily as needed; may increase dosage as needed, approximately 0.2 to 0.4 mg/kg/day in divided doses every 6 to 8 hours
>=6 years: 5 mL orally daily as needed; may increase dosage as needed up to a maximum of 24 mg/day in divided doses every 6 to 8 hours

Tablet (carbinoxamine maleate 4 mg):
<2 years: Safety and effectiveness unknown
2 to 6 years: 1/2 tablet orally daily as needed; may increase dosage as needed, approximately 0.2 to 0.4 mg/kg/day in divided doses every 6 to 8 hours
>=6 years: 1 tablet orally daily as needed; may increase dosage as needed up to a maximum of 24 mg/day in divided doses every 6 to 8 hours

Usual Pediatric Dose for Dermatographism

Solution (carbinoxamine maleate 4 mg/5 mL):
<2 years: Safety and effectiveness unknown
2 years to 6 years: 2.5 mL orally daily as needed; may increase dosage as needed, approximately 0.2 to 0.4 mg/kg/day in divided doses every 6 to 8 hours
>=6 years: 5 mL orally daily as needed; may increase dosage as needed up to a maximum of 24 mg/day in divided doses every 6 to 8 hours

Tablet (carbinoxamine maleate 4 mg):
<2 years: Safety and effectiveness unknown
2 to 6 years: 1/2 tablet orally daily as needed; may increase dosage as needed, approximately 0.2 to 0.4 mg/kg/day in divided doses every 6 to 8 hours
>=6 years: 1 tablet orally daily as needed; may increase dosage as needed up to a maximum of 24 mg/day in divided doses every 6 to 8 hours

Usual Pediatric Dose for Vasomotor Rhinitis

Solution (carbinoxamine maleate 4 mg/5 mL):
<2 years: Safety and effectiveness unknown
2 years to 6 years: 2.5 mL orally daily as needed; may increase dosage as needed, approximately 0.2 to 0.4 mg/kg/day in divided doses every 6 to 8 hours
>=6 years: 5 mL orally daily as needed; may increase dosage as needed up to a maximum of 24 mg/day in divided doses every 6 to 8 hours

Tablet (carbinoxamine maleate 4 mg):
<2 years: Safety and effectiveness unknown
2 to 6 years: 1/2 tablet orally daily as needed; may increase dosage as needed, approximately 0.2 to 0.4 mg/kg/day in divided doses every 6 to 8 hours
>=6 years: 1 tablet orally daily as needed; may increase dosage as needed up to a maximum of 24 mg/day in divided doses every 6 to 8 hours

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

Antihistamines such as carbinoxamine should not be used in newborn or premature infants.

Reports of excitability in children (i.e. < 18 years) receiving carbinoxamine therapy has rarely been reported.

Antihistamines are more likely to cause dizziness, sedation, and hypotension in elderly patients (i.e. >=60 years). Because of its anticholinergic properties, carbinoxamine meets the Beers criteria as a medication that is potentially inappropriate for use in older adults. Nonanticholinergic antihistamines are preferred in elderly patients when treating allergic reactions.

Dialysis

Data not available

Other Comments

Dosage should be titrated individually depending on patient response and severity of symptoms. The lowest effective dosage should be used to minimize sedation and other adverse effects.