Drug Detail:Carisoprodol (Carisoprodol [ kar-eye-soe-proe-dole ])
Drug Class: Skeletal muscle relaxants
Usual Adult Dose for Muscle Spasm
250 to 350 mg orally 3 times a day and at bedtime
Duration of therapy: Up to 2 to 3 weeks
Comments:
- This drug should only be used for short periods (up to 2 or 3 weeks) as there is inadequate evidence of effectiveness for more prolonged use and acute, painful musculoskeletal conditions are generally of short duration.
Use: For the relief of discomfort associated with acute, painful musculoskeletal conditions
Renal Dose Adjustments
Use with caution
Liver Dose Adjustments
Use with caution
Dose Adjustments
Patients with Reduced CYP450 2C19 Activity:
- Use with caution as higher exposure to carisoprodol and lower exposure to meprobamate (active metabolite) is expected; the clinical significance of this is not known.
Precautions
Safety and efficacy have not been established in patients younger than 16 years or over 65 years.
US Controlled Substance: Schedule IV
Dialysis
Dialyzable by peritoneal and hemodialysis.
Other Comments
Administration advice:
Take orally with or without food
General:
- Dependence, withdrawal, and abuse have been reported with prolonged use; duration of use should be limited to less than 3 weeks.
Monitoring:
- Monitor for sedation
- Monitor for signs of abuse and overdose
Patient advice:
- Patients should avoid taking this drug prior to engaging in potentially hazardous activities as this drug has been associated with motor vehicle accidents.
- Patients should avoid alcohol while on this drug and check with their healthcare provider before taking other CNS depressants.
- Patients should be informed that this drug has been associated with cases of dependence, withdrawal, and abuse; use should be limited to less than 3 weeks duration.
Frequently asked questions
- What is Caridoxen used for?
