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Home > Drugs > Succinimide anticonvulsants > Ethosuximide > Ethosuximide Dosage
Succinimide anticonvulsants
https://themeditary.com/dosage-information/ethosuximide-dosage-11256.html

Ethosuximide Dosage

Drug Detail:Ethosuximide (Ethosuximide [ eth-oh-sux-i-mide ])

Drug Class: Succinimide anticonvulsants

Contents
Uses Warnings Before Taking Dosage Side effects Interactions

Usual Adult Dose for Seizures

Initial dose: 500 mg orally once a day

  • Increase dose in small increments, for example 250 mg daily every 4 to 7 days, until optimal seizure control with minimal side effects is achieved
Maintenance dose: Individualized; generally, a dose that provides efficacy and tolerability with a plasma level within the accepted therapeutic range (40 to 100 mcg/mL)

Comments:
  • Doses exceeding 1.5 g per day should be administered only under strict supervision of a physician.
  • For higher daily doses, consider twice a day dosing.
  • This drug may be administered in combination with other anticonvulsants when other forms of epilepsy coexist.

Use: For the control of absence (petit mal) seizures.

Usual Pediatric Dose for Seizures

3 to 6 years old:
Initial dose: 250 mg orally once a day

6 years or older:
Initial dose: 500 mg orally once a day

Titration: Increase dose in small increments, for example 250 mg daily every 4 to 7 days, until optimal seizure control with minimal side effects is achieved
Maintenance dose: Individualized; generally, a dose that provides efficacy and tolerability with a plasma level within the accepted therapeutic range (40 to 100 mcg/mL)
Optimal dose for most pediatric patients: 20 mg/kg/day; some authorities have found doses up to 40 mg/kg/24 hours are needed to obtain therapeutic levels

Comments:

  • Doses exceeding 1.5 g per day should be administered only under strict supervision of a physician.
  • For higher daily doses, consider twice a day dosing.
  • This drug may be administered in combination with other anticonvulsants when other forms of epilepsy coexist.

Use: For the control of absence (petit mal) seizures.

Renal Dose Adjustments

Renal disease: Administer with extreme caution

Liver Dose Adjustments

Liver disease: Administer with extreme caution

Dose Adjustments

Therapeutic blood level monitoring:

  • Accepted therapeutic range: 40 to 100 mcg/mL

Concomitant Use with other Antiepileptic Drugs
  • Periodic serum level determinations of antiepileptic drugs may be necessary
  • This drug may elevate phenytoin serum levels
  • Valproic acid may both increase and decrease ethosuximide levels

Changes to Dosing Regimen:
  • Dose changes, as well as, the addition and/or elimination of other antiepileptic medications should be done slowly; avoid abrupt withdrawal

Precautions

NARROW THERAPEUTIC INDEX:

  • This drug should be considered a narrow therapeutic index (NTI) drug as small differences in dose or blood concentrations may lead to serious therapeutic failures or adverse drug reactions.
Recommendations:
  • Generic substitution should be done cautiously, if at all, as current bioequivalence standards are generally insufficient for NTI drugs.
  • Additional and/or more frequent monitoring should be done to ensure receipt of an effective dose while avoiding unnecessary toxicities.

CONTRAINDICATIONS:
  • Hypersensitivity to succinimides

Safety and efficacy have not been established in patients younger than 3 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:

  • Take orally
  • An adequately calibrated measuring device such as an oral syringe, should be used to measure liquid doses

Storage requirements:
  • Oral solution: Protect from freezing and light

General:
  • Using this drug as monotherapy in patients with mixed type of epilepsy may increase the frequency of grand mal seizures in some patients.
  • Abrupt withdrawal may precipitate seizures; as with other antiepileptic drugs, dose increases and decreases should proceed slowly.

Monitoring:
  • Blood counts, periodically, and if signs and/or symptoms of infection develop
  • Urinalysis periodically
  • Liver function tests periodically
  • Monitor for the emergence or worsening of depression, suicidal thoughts or behavior, and/or any unusual changes in mood or behavior
  • Monitor for rash

Patient advice:
  • Read the US FDA-approved patient labeling (Patient Information).
  • Patients should understand the importance of strictly adhering to their dosing regimen.
  • Patients should be appropriately counseled regarding the performance of potentially hazardous tasks.
  • Patients should be instructed to contact their healthcare provider promptly if they develop a rash or signs and symptoms of an infection.
  • Patients and/or caregivers should monitor for the emergence or worsening of depression, suicidal thoughts or behavior, and/or any unusual changes in mood or behavior; behaviors of concern should be reported promptly.
  • Women of childbearing potential should speak with their physician if they are or intend to become pregnant, or are breastfeeding.
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