2.1 General Considerations

Dose once-daily. The dosage may be increased after 2 weeks of therapy. The full blood pressure lowering effect was achieved 2 weeks after being on the maximal dose of Exforge HCT. The maximum recommended dose of Exforge HCT is 10/320/25 mg.

2.2 Add-on/Switch Therapy

Exforge HCT may be used for patients not adequately controlled on any 2 of the following antihypertensive classes: calcium channel blockers, angiotensin receptor blockers, and diuretics.

A patient who experiences dose-limiting adverse reactions to an individual component while on any dual combination of the components of Exforge HCT may be switched to Exforge HCT containing a lower dose of that component to achieve similar blood pressure reductions.

2.3 Replacement Therapy

Exforge HCT may be substituted for the individually titrated components.

2.4 Use With Other Antihypertensive Drugs

Exforge HCT may be administered with other antihypertensive agents.