Drug Detail:Fluocinolone (eent) (monograph) (Retisert)
Drug Class:
Usual Adult Dose for Uveitis
1 implant, containing 1 tablet of 0.59 mg of fluocinolone acetonide, to be surgically implanted into the posterior segment of the affected eye through a pars plana incision
Comments:
- Following depletion of this drug as evidenced by recurrence of uveitis, the implant may be replaced.
- Caution should be used in handling the implant to avoid damage, which may result in an increased rate of drug release from the implant.
- Care should be taken during implantation and explantation to avoid sheer forces on the implant that could disengage the silicone cup reservoir from the suture tab.
- Aseptic technique should be maintained at all times prior to and during the surgical implantation procedure.
- The implant should not be resterilized by any method.
Use: Treatment of chronic non-infectious uveitis affecting the posterior segment of the eye
Usual Adult Dose for Macular Edema
1 implant, containing 0.19 mg of fluocinolone acetonide, to be surgically implanted inferior to the optic disc and posterior to the equator of the eye
Comments:
- For ophthalmic intravitreal injection.
- Aseptic technique should be maintained at all times prior to and during the surgical implantation procedure. Consult the manufacturer product information for proper handling.
- Patients should be monitored for elevation in intraocular pressure and for endophthalmitis.
- Patients should be instructed to report any symptoms suggestive of endophthalmitis.
Use: Treatment of diabetic macular edema in patients who have been previously treated with a course of corticosteroids and did not have a clinically significant rise in intraocular pressure.
Usual Pediatric Dose for Uveitis
12 years or older:
1 implant, containing 1 tablet of 0.59 mg of fluocinolone acetonide, to be surgically implanted into the posterior segment of the affected eye through a pars plana incision
Comments:
- Following depletion of this drug as evidenced by recurrence of uveitis, the implant may be replaced.
- Caution should be used in handling the implant to avoid damage, which may result in an increased rate of drug release from the implant.
- Care should be taken during implantation and explantation to avoid sheer forces on the implant that could disengage the silicone cup reservoir from the suture tab.
- Aseptic technique should be maintained at all times prior to and during the surgical implantation procedure.
- The implant should not be resterilized by any method.
Use: Treatment of chronic non-infectious uveitis affecting the posterior segment of the eye
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Data not available
Precautions
0.19 mg intravitreal implant: Safety and efficacy have not been established in patients younger than 18 years.
0.59 mg intravitreal implant: Safety and efficacy have not been established in patients younger than 12 years.
Consult WARNINGS section for additional precautions.
Dialysis
Data not available
Other Comments
Administration advice:
- The manufacturer product information should be consulted.
Storage requirements:
- Do not refrigerate or freeze.
- Do not open the sealed tray until just before application
Frequently asked questions
- What are the differences between Iluvien, Retisert and Yutiq intravitreal implants?
