Usual Adult Dose for Hypertriglyceridemia

2 g orally twice a day with food

Comments:

• Limitations of Use: The effect of this drug on the risk for pancreatitis in patients with severe hypertriglyceridemia has not been determined.

• As an adjunct to diet to reduce triglyceride (TG) levels in patients with severe (500 mg/dL or greater) hypertriglyceridemia
• As an adjunct to maximally tolerated statin therapy to reduce the risk of myocardial infarction, stroke, coronary revascularization, and unstable angina requiring hospitalization in patients with elevated TG levels (150 mg/dL or higher) and: established cardiovascular disease OR diabetes mellitus and at least 2 additional risk factors for cardiovascular disease

Usual Adult Dose for Cardiovascular Risk Reduction

2 g orally twice a day with food

Comments:

• Limitations of Use: The effect of this drug on the risk for pancreatitis in patients with severe hypertriglyceridemia has not been determined.

• As an adjunct to diet to reduce triglyceride (TG) levels in patients with severe (500 mg/dL or greater) hypertriglyceridemia
• As an adjunct to maximally tolerated statin therapy to reduce the risk of myocardial infarction, stroke, coronary revascularization, and unstable angina requiring hospitalization in patients with elevated TG levels (150 mg/dL or higher) and: established cardiovascular disease OR diabetes mellitus and at least 2 additional risk factors for cardiovascular disease

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Comments:

• In patients with liver dysfunction, ALT and AST levels should be monitored periodically during therapy.

Precautions

CONTRAINDICATIONS:

• Known hypersensitivity (e.g., anaphylactic reaction) to the active component or any of the ingredients

Dialysis

Data not available

Other Comments

Administration advice:

• Prior to initiating therapy, assess lipid levels; identify other causes (e.g., diabetes mellitus, hypothyroidism, medications) of high TG levels and manage as appropriate.
• Before receiving this drug, patients should engage in appropriate nutritional intake and physical activity, and this should continue during treatment.
• Administer with or after a meal.
• Swallow capsules whole; do not break open, crush, dissolve, or chew.

• Hematologic: Bleeding time in patients on concomitant agents affecting coagulation
• Hepatic: ALT and AST in patients with liver dysfunction (periodically during therapy)
• Metabolic: Lipid levels (prior to initiating therapy)

• Before starting this drug, read the US FDA-approved patient labeling (Patient Information).
• Discontinue therapy and seek medical attention if allergic reactions develop.
• If a dose is missed, take it as soon as remembered; however, if you miss 1 day of this drug, do not double the dose when you take it.

Frequently asked questions

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