Adrenergic bronchodilators
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Isuprel Dosage

Drug Detail:Isuprel hcl (Isoproterenol injection [ eye-so-proe-ter-e-nole ])

Generic Name: ISOPROTERENOL HYDROCHLORIDE 0.2mg in 1mL

Dosage Form: injection, solution

Drug Class: Adrenergic bronchodilators Catecholamines

Contents
Uses Warnings Before Taking Dosage Side effects Interactions

General Considerations

Inspect visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Do not use if the injection is pinkish or darker than slightly yellow or contains a precipitate. Discard any unused portion.

Diluted solution should be used immediately. Unused material should be discarded.

Recommended Dosage

Dosage should generally be started at the lowest recommended dose and increased gradually based on patient response.
*
Concentrations up to 10 times greater have been used when limitation of volume is essential.
†
Rates over 30 mcg per minute have been used in advanced stages of shock. Adjust the rate of infusion based on heart rate, central venous pressure, systemic blood pressure, and urine flow. If the heart rate exceeds 110 beats per minute, consider decreasing or temporarily discontinuing the infusion.

Recommended dosage for adults with shock and hypoperfusion states:

Route of Administration

Preparation of Dilution*

Infusion Rate†

Intravenous infusion

Dilute 5 mL (1 mg) in 500 mL of 5% Dextrose Injection,

USP

0.5 mcg to 5 mcg per minute (0.25 mL to 2.5 mL of diluted solution)

Recommended dosage for adults with bronchospasm occurring during anesthesia:

Route of

Subsequent

Administration

Preparation of Dilution

Initial Dose

Dose

Bolus

intravenous
injection

Dilute 1 mL (0.2 mg) to 10 mL with Sodium Chloride Injection, USP, or 5% Dextrose Injection, USP

10 mcg to 20 mcg (0.5 mL to 1 mL of diluted solution)

The initial dose may be

repeated when necessary

There are no well-controlled studies in children to establish appropriate dosing; however, the American Heart Association recommends an initial infusion rate of 0.1 mcg/kg/min, with the usual range being 0.1 mcg/kg/min to 1 mcg/kg/min.

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