Magnesium elimination is decreased in renal impairment.
Digestive magnesium absorption is normal or decreased in renal impairment.
Liver Dose Adjustments
Data not available
Dialysis
Dose adjustment(s) may be required; however, no specific guidelines have been suggested. Caution is recommended.
Effects are similar in both hemodialysis and peritoneal dialysis.
Hypermagnesemia is common with creatinine clearance under 10 mL/min.
Mild hypermagnesemia is common with a dialysate magnesium of 0.75 mmol/L
Serum magnesium was normal to low with a dialysate magnesium between 0.2 and 0.25 mmol/L.
Ionized serum, ionized mononuclear and red blood cell measurements are not useful for hypermagnesemia detection.
Other Comments
Administration advice:
Take with food to prevent side effects.
Long acting formulations should not be crushed or chewed.
If a dose is missed, take it as soon as remembered, unless it's almost time for the next dose, in which case it should be skipped. Do not double up doses.
Patient advice:
Notify your doctor if you experience side effects that are severe or don't go away, such as diarrhea and stomach upset.
