Dosage for the Prevention of P. jirovecii Pneumonia

The recommended oral dosage is 1,500 mg (10 mL) once daily administered with food.

Dosage for the Treatment of Mild-to-Moderate P. jirovecii Pneumonia

The recommended oral dosage is 750 mg (5 mL) twice daily (total daily dose = 1,500 mg) administered with food for 21 days.

Important Administration Instructions

Administer MEPRON oral suspension with food to avoid low plasma atovaquone concentrations that may limit response to therapy [see Warnings and Precautions (5.1), Clinical Pharmacology (12.3)].

MEPRON Foil Pouch

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Open each 5-mL pouch by folding along the dotted line and tearing open at horizontal slit as directed by arrow on pouch.

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For a 5-mL dose, take entire contents either by placing directly into the mouth or by dispensing into a dosing spoon (5 mL) or cup prior to administration by mouth.

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For a 10-mL dose, take the entire contents of 2 pouches.

MEPRON Bottle

Shake bottle gently before administering the recommended dosage.