Drug Detail:Methylergonovine (oral and injection) (Methylergonovine (oral and injection) [ meth-il-er-gon-o-veen ])
Drug Class: Uterotonic agents
Usual Adult Dose for Postpartum Bleeding
Parenteral:
0.2 mg IM after delivery of the placenta or during the puerperium; may be repeated at intervals of 2 to 4 hours as required
Orally:
0.2 mg orally 3 or 4 times a day for a maximum of 1 week during the puerperium
Comments:
- Under full obstetric supervision, this drug may be given parenterally during the second stage of labor following delivery of the anterior shoulder.
- IV administration should be avoided unless administration is considered life-saving; IV dosing is the same as IM, give IV slowly over at least 60 seconds
Uses:
- For routine management of uterine atony, hemorrhage and subinvolution of the uterus following delivery of the placenta.
- For control of uterine hemorrhage in the second stage of labor following delivery of the anterior shoulder.
Renal Dose Adjustments
Use caution
Liver Dose Adjustments
Use caution
Precautions
CONTRAINDICATIONS:
- Hypersensitivity
- Hypertension
- Toxemia
- Pregnancy
Safety and efficacy have not been established in patients younger than 18 years.
Consult WARNINGS section for additional precautions.
Dialysis
Data not available
Other Comments
Administration advice:
- For oral and IM administration; avoid intra-arterial or periarterial administration
- Routine IV administration should be avoided because of the possibility of sudden hypertensive and cerebrovascular accidents; if administered IV, give slowly over no less than 60 seconds and closely monitor blood pressure
Storage requirements:
- Protect from light
General:
- Methergine injection should be stored separately from medications intended for neonatal administration to avoid inadvertent administration to newborn infants.
Monitoring:
- Monitor BP, especially if IV administration is necessary