Drug Detail:Nystatin (Nystatin (oral) [ nye-stat-in ])
Drug Class: Mouth and throat products Polyenes
Usual Adult Dose for Oral Thrush
Recommended dose: 400,000 to 600,000 units of the oral suspension orally 4 times a day
Duration of therapy: At least 48 hours after symptoms have disappeared and cultures demonstrate eradication
Comment:
- For the treatment of oral candidiasis, the suspension should be retained in the mouth for as long as possible before swallowing.
Use: Treatment of oral candidiasis in the oral cavity
Usual Adult Dose for Intestinal Candidiasis
Recommended dose: 500,000 to 1,000,000 units of the tablet formulation orally 3 times a day
Duration of therapy: At least 48 hours after clinical cure
Use: Treatment of non-esophageal mucus membrane gastrointestinal candidiasis
Usual Pediatric Dose for Oral Thrush
1 month to 12 months:
- Recommended dose: 200,000 units of the oral suspension orally 4 times a day
- Recommended dose: 400,000 to 600,000 units of the oral suspension orally 4 times a day
- Duration of therapy: At least 48 hours after symptoms have disappeared and cultures demonstrate eradication
Comments:
- Limited data in premature and low birth weight infants indicated efficacy with 100,000 units orally 4 times a day.
- Infants should avoid feeding for 5 to 10 minutes after administration.
- For the treatment of oral candidiasis, the suspension should be retained in the mouth for as long as possible before swallowing.
Use: Treatment of oral candidiasis in the oral cavity
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Data not available
Precautions
Consult WARNINGS section for additional precautions.
Dialysis
Data not available
Other Comments
Administration advice:
- Patients should shake the oral suspension well prior to use, and the suspension should be administered by placing half of the dose in each side of the mouth with a dropper.
Storage requirements:
- The manufacturer product information should be consulted.
General:
- This drug is fungistatic and fungicidal in yeasts and yeast-like fungi; it is not active against organisms lacking sterols in their cell membranes.
Monitoring:
- Signs/symptoms of candidiasis (e.g., cultures)
- Hypersensitivity reactions
Patient advice:
- Patients should continue treatment for at least 48 hours after symptoms disappear and/or cultures are negative for Candida albicans.
- Patients should be instructed to report signs/symptoms of hypersensitivity reactions.
- Patients should be told to immediately contact their healthcare providers if symptoms worsen and/or are not improved after 14 days.
Frequently asked questions
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