Usual Adult Dose for Skin and Structure Infection

1200 mg via IV infusion (over 3 hours) once

Comment: This drug should be given as a single dose.

Use: For the treatment of acute bacterial skin and skin structure infections due to susceptible isolates of Staphylococcus aureus (including methicillin-susceptible and methicillin-resistant isolates), Streptococcus pyogenes, S agalactiae, S dysgalactiae, S anginosus group (includes S anginosus, S intermedius, and S constellatus), and Enterococcus faecalis (vancomycin-susceptible isolates only)

Renal Dose Adjustments

Mild or moderate renal dysfunction (CrCl 30 to 79 mL/min): No adjustment recommended.
Severe renal dysfunction (CrCl less than 30 mL/min): Data not available

Liver Dose Adjustments

Mild or moderate liver dysfunction (Child-Pugh A or B): No adjustment recommended.
Severe liver dysfunction (Child-Pugh C): Data not available

Precautions

CONTRAINDICATIONS:

• Hypersensitivity to the active component or any of the ingredients
• Use of IV unfractionated heparin sodium for 120 hours (5 days) after administration

Dialysis

Data not available

Comment: This drug is not removed by hemodialysis.

Other Comments

Administration advice:

• Administer via IV infusion over 3 hours; reconstitute and dilute prior to infusion.
• Slow the rate or interrupt infusion if infusion reaction occurs.
• If same IV line is used for sequential infusion of additional drugs, line should be flushed before and after infusion of this drug with 5% dextrose in sterile water (D5W); the manufacturer product information should be consulted.

• Vials of lyophilized powder: Should store at 20C to 25C (68F to 77F); excursions to 15C to 30C (59F to 86F) permitted
• Diluted IV solution in infusion bag: Should use within 6 hours when stored at room temperature or within 12 hours when refrigerated at 2C to 8C (36F to 46F)
• Combined storage time (reconstituted solution in vial and diluted solution in bag) and infusion time (3 hours) should not exceed 6 hours at room temperature or 12 hours if refrigerated.

• Compatible: D5W
• Incompatible: Normal saline (including other IV substances, additives, or other drugs mixed in normal saline), drugs formulated at a basic or neutral pH

• Limitations of use: Safety and efficacy in patients with bacteremia, peripheral vascular disease, neutropenia, those who are immunocompromised, over 65 years, and/or with infections caused by Streptococcus pyogenes have not been established.

• Infections/Infestations: For signs/symptoms of osteomyelitis
• Hematologic: For signs of bleeding in patients on chronic warfarin (frequently)
• Hypersensitivity: For signs of hypersensitivity in patients with glycopeptide allergy (during infusion)

• Patients should be advised to avoid missing doses and to complete the entire course of therapy.
• Patients should be told to immediately report any signs/symptoms of a hypersensitivity reaction.
• Patients should be instructed to report signs/symptoms of C difficile (e.g., watery/bloody stools, stomach cramps, fever), for up to 2 months after stopping treatment.