Hereditary angioedema agents
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Orladeyo Dosage

Drug Detail:Orladeyo (Berotralstat [ ber-oh-tral-stat ])

Generic Name: Berotralstat hydrochloride 150mg

Dosage Form: capsule

Drug Class: Hereditary angioedema agents

Contents
Uses Warnings Before Taking Dosage Side effects Interactions

Recommended Dosage

The recommended dosage of ORLADEYO is one 150 mg capsule taken orally once daily with food.

Recommended Dosage in Patients with Hepatic Impairment

No dosage adjustment of ORLADEYO is recommended for patients with mild hepatic impairment (Child-Pugh Class A) [see Use in Specific Populations (8.7) and Clinical Pharmacology (12.3)].

In patients with moderate or severe hepatic impairment (Child-Pugh B or C), the recommended dosage of ORLADEYO is one 110 mg capsule taken orally once daily with food [see Use in Specific Populations (8.7) and Clinical Pharmacology (12.3)].

Recommended Dosage for Concomitant Use with P-gp or BCRP Inhibitors

In patients with chronic administration of P-gp or BCRP inhibitors (e.g., cyclosporine), the recommended dosage of ORLADEYO is one 110 mg capsule taken orally once daily with food [see Drug Interactions (7.1) and Clinical Pharmacology (12.3)].

Dosage Adjustment in Patients with Persistent GI Reactions

Gastrointestinal (GI) reactions may occur in patients receiving ORLADEYO [see Adverse Reactions (6.1)]. If GI events persist, a reduced dose of 110 mg once daily with food may be considered.

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