Drug Detail:Prevacid (Lansoprazole [ lan-soe-pra-zol ])
Generic Name: lansoprazole 15mg
Dosage Form: capsule, delayed release, tablet, orally disintegrating, delayed release
Drug Class: Proton pump inhibitors
Recommended Adult Dosage by Indication
| Indication | Recommended Dose | Frequency |
|---|---|---|
|
||
| Duodenal Ulcers | ||
| Short-Term Treatment | 15 mg | Once daily for 4 weeks |
| Maintenance of Healed | 15 mg | Once daily |
| Eradication of H. pylori to Reduce the Risk of Duodenal Ulcer Recurrence* | ||
| Triple Therapy: | ||
| PREVACID or PREVACID SoluTab | 30 mg | Twice daily for 10 or 14 days |
| Amoxicillin | 1 gram | Twice daily for 10 or 14 days |
| Clarithromycin | 500 mg | Twice daily for 10 or 14 days |
| Dual Therapy: | ||
| PREVACID or PREVACID SoluTab | 30 mg | Three times daily for 14 days |
| Amoxicillin | 1 gram | Three times daily for 14 days |
| Benign Gastric Ulcer | ||
| Short-Term Treatment | 30 mg | Once daily for up to 8 weeks |
| NSAID-Associated Gastric Ulcer | ||
| Healing | 30 mg | Once daily for 8 weeks† |
| Risk Reduction | 15 mg | Once daily for up to 12 weeks† |
| Gastroesophageal Reflux Disease (GERD) | ||
| Short-Term Treatment of Symptomatic GERD | 15 mg | Once daily for up to 8 weeks |
| Short-Term Treatment of Erosive Esophagitis | 30 mg | Once daily for up to 8 weeks‡ |
| Maintenance of Healing of Erosive Esophagitis | 15 mg | Once daily§ |
| Pathological Hypersecretory Conditions Including Zollinger-Ellison Syndrome | 60 mg | Once daily¶ |
Recommended Pediatric Dosage by Indication
Pediatric Patients 1 to 11 Years of Age
In clinical studies, PREVACID was not administered beyond 12 weeks in 1 to 11 year olds. It is not known if PREVACID is safe and effective if used longer than the recommended duration. Do not exceed the recommended dose and duration of use in pediatric patients as outlined below [see Use in Specific Populations (8.4)].
| Indication | Recommended Dose | Frequency |
|---|---|---|
| Short-Term Treatment of Symptomatic GERD and Short-Term Treatment of Erosive Esophagitis | ||
| ≤30 kg | 15 mg | Once daily for up to 12 weeks |
| >30 kg | 30 mg | Once daily for up to 12 weeks |
Hepatic Impairment
The recommended dosage is 15 mg orally daily in patients with severe liver impairment (Child-Pugh C) [see Use in Specific Populations (8.6)].
Important Administration Information
- Take PREVACID or PREVACID SoluTab before meals.
- Do not crush or chew PREVACID capsule or PREVACID SoluTab.
- Take PREVACID or PREVACID SoluTab at least 30 minutes prior to sucralfate [see Drug Interactions (7)].
- Antacids may be used concomitantly with PREVACID or PREVACID SoluTab.
- Missed doses: If a dose is missed, administer as soon as possible. However, if the next scheduled dose is due, do not take the missed dose, and take the next dose on time. Do not take two doses at one time to make up for a missed dose.
PREVACID capsules
- Swallow whole; do not chew.
- For patients who have difficulty swallowing capsules, PREVACID capsules can be opened and administered orally or via a nasogastric tube in the soft foods or liquids specified below.
- Administration of PREVACID in foods or liquids other than those discussed below have not been studied clinically and therefore are not recommended.
Administration in Soft Foods (applesauce, ENSURE pudding, cottage cheese, yogurt or strained pears):- Open capsule.
- Sprinkle intact granules on one tablespoon of either applesauce, ENSURE pudding, cottage cheese, yogurt or strained pears.
- Swallow immediately.
- Open capsule.
- Sprinkle intact granules into a small volume of either apple juice, orange juice or tomato juice (60 mL – approximately two ounces).
- Mix briefly.
- Swallow immediately.
- To ensure complete delivery of the dose, rinse the glass with two or more volumes of juice and swallow the contents immediately.
- Open capsule.
- Sprinkle intact granules into 40 mL of apple juice.
- Mix briefly.
- Using a catheter -tipped syringe, draw up the mixture.
- Inject through the nasogastric tube into the stomach.
- Flush with additional apple juice to clear the tube.
PREVACID SoluTab
- Do not break or cut.
- Place the tablet on the tongue, allow it to disintegrate, with or without water, until the microgranules can be swallowed. Do not chew the microgranules.
- The tablet typically disintegrates in less than one minute.
- Alternatively, for children or other patients who have difficulty swallowing tablets, PREVACID SoluTab can be administered with water via oral syringe or NG tube as follows:
Administration with Water in an Oral Syringe- Place a 15 mg tablet in oral syringe and draw up 4 mL of water, or place a 30 mg tablet in oral syringe and draw up 10 mL of water.
- Shake gently to allow for a quick dispersal.
- After the tablet has dispersed, administer the contents within 15 minutes of mixing into the mouth. Do not save the water and microgranule mixture for later use.
- Refill the syringe with approximately 2 mL (5 mL for the 30 mg tablet) of water, shake gently, and administer any remaining contents.
- Place a 15 mg tablet in a catheter-tip syringe and draw up 4 mL of water, or place a 30 mg tablet in a catheter-tip syringe and draw up 10 mL of water.
- Shake gently to allow for a quick dispersal.
- After the tablet has dispersed, shake the catheter-tip syringe gently in order to keep the microgranules from settling, and immediately inject the mixture through the NG tube into the stomach within 15 minutes of mixing. Do not save the water and microgranule mixture for later use.
- Refill the catheter-tip syringe with approximately 5 mL of water, shake gently, and flush the tube.
