Agents for pulmonary hypertension
https://themeditary.com/dosage-information/revatio-dosage-3917.html

Revatio Dosage

Drug Detail:Revatio (Sildenafil (oral) [ sil-den-a-fil ])

Generic Name: SILDENAFIL CITRATE 20mg

Drug Class: Agents for pulmonary hypertension

Contents
Uses Warnings Before Taking Dosage Side effects Interactions

Recommended Dosage in Adults

​Oral Dosage

​The recommended dosage of REVATIO is 20 mg three times a day. Dose may be titrated to a maximum of 80 mg three times a day, if required, based on symptoms and tolerability [see Clinical Studies (14)].

​Although dose-response improvement in exercise ability was not observed in short-term studies in adults with PAH, the delay in clinical worsening with long-term use of sildenafil in Study A1481324 supports dosing up to a maximum of 80 mg three times a day [see Clinical Studies (14)].

Intravenous Dosage

​The recommended dose is 10 mg administered as an intravenous bolus injection three times a day. The dose of REVATIO injection does not need to be adjusted for body weight.

​A 10-mg dose of REVATIO injection is predicted to provide pharmacological effect of sildenafil and its N-desmethyl metabolite equivalent to that of a 20-mg oral dose.

Recommended Dosage in Pediatric Patients

​Oral Dosage

​The recommended dosage in patients ≤20 kg is 10 mg three times a day.

​For pediatric patients 20 kg to 45 kg, the recommended dosage is 20 mg three times a day.

​For pediatric patients 45 kg and greater, the recommended dosage is 20 mg three times a day. A maximum dose in pediatric patients has not been identified. Based on the experience in adults, dose may be titrated to a maximum of 40 mg three times a day for pediatric patients >45 kg, if required, based on symptoms and tolerability [see Clinical Studies (14)].

Reconstitution of the Powder for Oral Suspension

​Note: Reconstitute the contents of the bottle with a total volume of 90 mL (60 mL followed by 30 mL). Refer to the detailed instructions below.

1.
​Tap the bottle to loosen the powder.
2.
​Add 60 mL of water to the bottle.
3.
​Replace the cap and shake the bottle vigorously for a minimum of 30 seconds.
4.
​Add another 30 mL of water to the bottle.
5.
​Replace the cap and shake the bottle vigorously for a minimum of 30 seconds.
6.
​Remove cap and press the bottle adaptor into the neck of the bottle. Replace the cap on the bottle.
7.
​Write the expiration date of the reconstituted oral suspension on the bottle label (the expiration date of the reconstituted oral suspension is 60 days from the date of reconstitution).

Incompatibilities

Do not mix with any other medication or additional flavoring agent.

Share this Article
Latest News
Related Drugs