By using this site, you agree to the Privacy Policy and Terms of Use.
Accept
Medical Information, Documents, News - TheMediTary.Com Logo Medical Information, Documents, News - TheMediTary.Com Logo

TheMediTary.Com

Medical Information, Documents, News - TheMediTary.Com

  • Home
  • News
  • Drugs
  • Drugs A-Z
  • Medical Answers
  • About Us
  • Contact
Medical Information, Documents, News - TheMediTary.Com Logo Medical Information, Documents, News - TheMediTary.Com Logo
Search Drugs
  • Drugs
    • Latest Drugs
    • Drugs A-Z
    • Medical Answers
  • News
    • FDA Alerts
    • Medical News
    • Health
    • Consumer Updates
    • Children's Health
  • More TheMediTary.Com
    • About Us
    • Contact
Follow US
Home > Drugs > Antimetabolites > Siklos > Siklos Dosage
Antimetabolites
https://themeditary.com/dosage-information/siklos-dosage-4824.html

Siklos Dosage

Drug Detail:Siklos (Hydroxyurea [ hye-drox-ee-yoo-ree-a ])

Generic Name: hydroxyurea 1000mg

Dosage Form: tablet, film coated

Drug Class: Antimetabolites

Contents
Uses Warnings Before Taking Dosage Side effects Interactions

Recommended Dosing

The recommended SIKLOS dosing is described in Table 1.

Table 1: Dosing Recommendation Based on Blood Count
​Dosing Regimen Dose Dose Modification Criteria Monitoring Parameters
​Initial Recommended Dosing Adults: 15 mg/kg
Pediatrics: 20 mg/kg
once daily based on patient's actual or ideal weight, whichever is less.
Monitor the patient's blood count every 2 weeks [see Warnings and Precautions (5.1)].
​Dosing Adjustment Based on Blood Counts in an acceptable range Increase dose 5 mg/kg/day every 8 weeks or if a painful crisis occurs.
Give until mild myelosuppression (absolute neutrophil count 2,000/uL to 4,000/uL) is achieved, up to a maximum of 35 mg/kg/day.
Increase dosing only if blood counts are in an acceptable range.
Increase dosing if a painful crisis occurs.
Do not increase if myelosuppression occurs.
Blood Counts Acceptable Range:
- neutrophils greater than or equal to 2,000 cells/mm3
- platelets greater than or equal to 80,000/mm3
- hemoglobin greater than 5.3 g/dL
- reticulocytes greater than or equal to 80,000/mm3 if the hemoglobin concentration less than 9 g/dL
​Dosing Adjustment Based on Blood Counts in a toxic range Discontinue treatment. If blood counts are considered toxic, discontinue SIKLOS until hematologic recovery. Blood Counts Toxic Range:
-
neutrophils less than 2,000 cells/mm3
younger patients with lower baseline counts may safely tolerate absolute neutrophil counts down to 1,250/mm3.
- platelets less than 80,000/mm3
- hemoglobin less than 4.5 g/dL
- reticulocytes less than 80,000/mm3 if the hemoglobin concentration less than 9 g/dL
​Dosing After Hematologic Recovery Reduce dose by 5 mg/kg/day. Reduce the dose from the dose associated with hematologic toxicity.
May titrate up or down every 8 weeks in 5 mg/kg/day increments.
The patient should be at a stable dose with no hematologic toxicity for 24 weeks.
Discontinue the treatment permanently if a patient develops hematologic toxicity twice.

​Siklos is available in 100 mg and 1,000 mg tablets. The 100 mg tablets have 1 score line and can be split into 2 parts (each 50 mg). The 1,000 mg tablets have 3 score lines and can be split into 4 parts (each 250 mg). Therefore, the two strengths can be used to deliver doses of 1,000 mg, 750 mg, 500 mg, 250 mg, 100 mg, 50 mg and combinations thereof. Calculate the rounded doses to the nearest 50 mg or 100 mg strength based on clinical judgment.

​Patients must be able to follow directions regarding drug administration and their monitoring and care.

​Fetal hemoglobin (HbF) levels may be used to evaluate the efficacy of SIKLOS in clinical use. Obtain HbF levels every three to four months. Monitor for an increase in HbF of at least two-fold over the baseline value.

​Administration:

​The tablets should be taken once daily, at the same time each day, with a glass of water. For patients who are not able to swallow the tablets, these can be dispersed immediately before use in a small quantity of water in a teaspoon.

​SIKLOS is a cytotoxic drug. Follow applicable special handling and disposal procedures [see References (15)].

Dose Modifications for Renal Impairment

​Reduce the dose of SIKLOS by 50% in patients with creatinine clearance of less than 60 mL/min or with end-stage renal disease (ESRD) [see Use in Specific Populations (8.6) and Clinical Pharmacology (12.3)]. Obtain the creatinine clearance using a 24-hour urine collection.

Creatinine Clearance
(mL/min)
Recommended SIKLOS Initial Dose
(mg/kg daily)
Pediatrics Adults
*
​On dialysis days, administer SIKLOS to patients with ESRD following hemodialysis
Greater than or equal to 60 20 15
Less than 60 or ESRD* 10 7.5

​Monitor the hematologic parameters closely in these patients.

Share this Article
Latest News
Medical News

Seed oils: Omega-6 fatty acids may lower diabetes, heart disease risk

Jun 01, 2025
Type 2 diabetes: Sugary drinks may significantly raise risk
COVID-19: Who do the new vaccine guideline changes affect?
Vitamin D supplements may help slow down aging by 3 years
Aging: Exercise timing, consistency can affect heart and lung fitness
Heart health: Exercise not enough to offset effects of poor sleep
Related Drugs
Fidanacogene Elaparvovec
Cerave Anti-Itch
Centrum Adult
Crovalimab
Cyltezo Prefilled Syringe
Zepbound Pen
Mylanta One
Uretron Ds
Medihoney Wound And Burn Dressing
Lidotrode

Other drugs

Name Drug Class Updated
Fidanacogene Elaparvovec Drugs 03-Oct-2024
Cerave Anti-Itch Drugs 02-Oct-2024
Centrum Adult Drugs 02-Oct-2024
Crovalimab Drugs 02-Oct-2024
Cyltezo Prefilled Syringe Drugs 01-Oct-2024
Zepbound Pen Drugs 30-Sep-2024
Mylanta One Drugs 27-Sep-2024
Uretron Ds Drugs 27-Sep-2024
Medihoney Wound And Burn Dressing Drugs 26-Sep-2024
Lidotrode Drugs 26-Sep-2024
Libervant Drugs 26-Sep-2024
Moderna Covid-19 Drugs 25-Sep-2024
Beqvez Drugs 24-Sep-2024
Beqvez Drugs 24-Sep-2024
Beqvez Drugs 24-Sep-2024

Categories

  • FDA Alerts
  • Medical News
  • Health
  • Consumer Updates
  • Children's Health

About US

Welcome to TheMediTary.Com

Our website provides reliable and up-to-date information on various medical topics. We empower individuals to take charge of their health by simplifying complex medical jargon and providing practical tips and advice. We prioritize the privacy and confidentiality of our users and welcome feedback to improve our services.

Website use data of FDA and other sources

DMCA.com Protection Status Truste Protection Status Trust Mark Protection Status
HONcode logo We comply with the HONcode standard for trustworthy health information.
Quick Link
  • About Us
  • Contact Us
  • Editorial Policy
  • Privacy Policy
  • Accessibility Policy
  • Terms & Conditions
  • Disclaimer
  • DMCA
  • Do Not Sell My Personal Information
  • Sitemap
  • Care Notes
  • Health Guide
  • Professional
Drugs
  • New Drugs
  • Medical Answers
  • Drugs A-Z
  • Drug Classes
  • Drug Dosage
  • Pill Identifier
  • Consumer Infor
  • Side Effects
  • Inactive Ingredients
  • Pregnancy Warnings
  • Patient Tips
  • Treatments
News
  • Latest News
  • FDA Alerts
  • Medical News
  • Health
  • Consumer Updates
  • Children's Health
Find US
  • Medium
  • Google Site
  • Blogspot
  • API
  • Reddit
  • Tumblr
  • Scoop.it
  • Substack
  • Wordpress
  • Wix
  • Behance

© 2025 TheMediTary.Com All rights reserved. Operated by