Benzodiazepine anticonvulsants
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Valtoco Dosage

Drug Detail:Valtoco (Diazepam nasal [ dye-az-e-pam ])

Generic Name: diazepam 5mg in 0.1mL

Dosage Form: nasal spray

Drug Class: Benzodiazepine anticonvulsants

Contents
Uses Warnings Before Taking Dosage Side effects Interactions

Instructions Prior to Dosing

Prior to treatment, healthcare professionals should instruct the individual administering VALTOCO on how to identify seizure clusters and use the product appropriately [see Dosage and Administration (2.3) and Patient Counseling Information (17)].

Dosing Information

The recommended dose of VALTOCO nasal spray is 0.2 mg/kg or 0.3 mg/kg, depending on the patient's age and weight. See Table 1 for specific recommendations.

The following table provides the acceptable weight ranges for each dose and age category, such that patients will receive between 90% and 180% of the calculated recommended dose.

Table 1: Recommended Dosage for Adults and Pediatric Patients 6 Years of Age and Older
Dose Based on Age and Weight Administration
6 to 11 Years of Age
(0.3 mg/kg)		 12 Years of Age and Older
(0.2 mg/kg)		 Dose (mg) Number of Nasal Spray Devices Number of Sprays
Weight (kg) Weight (kg)
10 to 18 14 to 27 5 One 5 mg device One spray in one nostril
19 to 37 28 to 50 10 One 10 mg device One spray in one nostril
38 to 55 51 to 75 15 Two 7.5 mg devices One spray in each nostril
56 to 74 76 and up 20 Two 10 mg devices One spray in each nostril

Second Dose (if needed): A second dose, when required, may be administered after at least 4 hours after the initial dose. If the second dose is to be administered, use a new blister pack of VALTOCO.

Maximum Dosage and Treatment Frequency: Do not use more than 2 doses of VALTOCO to treat a single episode.

It is recommended that VALTOCO be used to treat no more than one episode every five days and no more than five episodes per month.

Important Administration Instructions

VALTOCO is for intranasal use only.

No device assembly is required. VALTOCO is a ready-to-use nasal spray device. VALTOCO nasal spray delivers its entire contents upon activation. Do not prime or attempt to use for more than one administration per device.

Patients and caregivers should be counseled to read carefully the "Instructions for Use" for complete directions on how to properly administer VALTOCO.

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