NK1 receptor antagonists
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Varubi Dosage

Drug Detail:Varubi (Rolapitant (oral - tablets) [ roe-la-pi-tant ])

Generic Name: ROLAPITANT HYDROCHLORIDE 90mg

Dosage Form: tablet

Drug Class: NK1 receptor antagonists

Contents
Uses Warnings Before Taking Dosage Side effects Interactions

The recommended dosage of VARUBI in adults in combination with a 5-HT3 receptor antagonist and dexamethasone for the prevention of nausea and vomiting with emetogenic cancer chemotherapy is shown in Table 1. There is no drug interaction between rolapitant and dexamethasone, so no dosage adjustment for dexamethasone is required. Administer a dexamethasone dose of 20 mg on Day 1 [see Clinical Pharmacology (12.3)].

Administer VARUBI prior to the initiation of each chemotherapy cycle, but at no less than 2 week intervals.

Administer VARUBI without regards to meals.

Table 1: Recommended Dosing Regimen of VARUBI
Day 1 Day 2 Day 3 Day 4
Prevention of Nausea and Vomiting Associated with Cisplatin-Based Highly Emetogenic Cancer Chemotherapy
VARUBI 180 mg as a single dose orally within 2 hours prior to initiation of chemotherapy None
Dexamethasone 20 mg; 30 min prior to initiation of chemotherapy 8 mg twice daily 8 mg twice daily 8 mg twice daily
5-HT3 receptor antagonist See the prescribing information for the co-administered 5-HT3 receptor antagonist for appropriate dosing information. None
Prevention of Nausea and Vomiting Associated with Moderately Emetogenic Cancer Chemotherapy and Combinations of Anthracycline and Cyclophosphamide
VARUBI 180 mg as a single dose orally within 2 hours prior to initiation of chemotherapy None
Dexamethasone 20 mg; 30 min prior to initiation of chemotherapy None
5-HT3 receptor antagonist See the prescribing information for the co-administered 5-HT3 receptor antagonist for appropriate dosing information. See the prescribing information for the co-administered 5-HT3 receptor antagonist for appropriate dosing information.
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