Bimatoprost ophthalmic (for the eyes) lowers pressure in the eye by increasing the amount of fluid that drains from the eye.

Bimatoprost ophthalmic implant (Durysta) is used to treat adults with open-angle glaucoma and other causes of high pressure inside the eye.

Bimatoprost ophthalmic implant may also be used for purposes not listed in this medication guide.

You should not be treated with Durysta if you have an eye infection, problems with your cornea, if you have had a corneal transplant, or if the sack around the lens of your eye is missing or torn.

Durysta is a tiny implant that is placed directly inside your eye (usually one per eye) by your eye doctor.

Your doctor may use a medicine to numb your eye before inserting the implant.

The Durysta implant will dissolve over time, and its effects should last for several months.

You should not be treated with Durysta if you are allergic to bimatoprost, or if you have:

• an infection in or around your eye;

• problems with your cornea (the surface of your eye);

• a history of corneal transplant; or

• if the sack around the lens of your eye (posterior lens capsule) is missing or torn.

Tell your doctor if you have ever had:

• eye problems in the space where your cornea meets your iris (the colored part of your eye);

• cataract surgery; or

• inflammation inside your eye.

Durysta may cause a gradual change in the color of brown eyes, usually an increase in pigment. This change occurs slowly and may be permanent even after your treatment ends.

Durysta is used as a single implant and does not have a daily dosing schedule.

Since bimatoprost ophthalmic implant is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Bimatoprost ophthalmic implant may cause serious side effects. Call your doctor at once if you have:

• worsening eye pain or redness;

• vision changes;

• increased sensitivity to light; or

• signs of eye infection--puffy eyelids, eye redness, severe discomfort, crusting or drainage, vision loss.

Common side effects of bimatoprost ophthalmic implant may include:

• eye redness or a blood spot on the white of your eye;

• eye pain;

• feeling like something is in your eye;

• eye dryness or irritation;

• blurred vision, inflammation of the iris;

• headache;

• increased pressure inside the eye; or

• a loss of cells on the inner layer of your cornea.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Medicine used in the eyes is not likely to be affected by other drugs you use. But many drugs can interact with each other. Tell each of your healthcare providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.