Clotrimazole is an antifungal medication that fights infections caused by fungus.

Clotrimazole vaginal (for use in the vagina) is used to treat vaginal candida (yeast) infections.

Clotrimazole vaginal may also be used for purposes not listed in this medication guide.

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Vaginal clotrimazole comes as a cream to be inserted into the vagina. It also may be applied to the skin around the outside of the vagina. The cream is inserted into the vagina once a day at bedtime for 3 or 7 days in a row, depending on the product instructions. The cream is used twice a day for up to 7 days around the outside of the vagina. Follow the directions on the package or your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use clotrimazole exactly as directed. Do not use more or less of it or use it more often than directed on the package or prescribed by your doctor.

Vaginal clotrimazole is available without a prescription (over the counter). If this is the first time you have had vaginal itching and discomfort, talk to a doctor before using clotrimazole. If a doctor has told you before that you had a yeast infection and you have the same symptoms again, use the vaginal cream as directed on the package.

Do not have vaginal intercourse or use other vaginal products (such as tampons, douches, or spermicides) during your treatment.

You should begin to feel better during the first three days of treatment with clotrimazole. If your symptoms do not improve or get worse, call your doctor.

To apply the clotrimazole cream to the outside area around the vagina, use your finger to apply a small amount of cream to the affected area of skin.

To insert the clotrimazole cream vaginally, read the instructions provided with the medication and follow these steps:

1. Fill the special applicator that comes with the cream to the level indicated.
2. Lie on your back with your knees drawn upward and spread apart or standing with your feet far apart and knees bent.
3. Gently insert the applicator into the vagina, and push the plunger to release the medication.
4. Withdraw the applicator.
5. Discard the applicator if it is disposable. If the applicator is reusable, pull it apart and clean it with soap and warm water after each use.
6. Wash your hands promptly to avoid spreading the infection.

The dose should be applied when you lie down to go to bed. It works best if you do not get up again after applying it except to wash your hands. You may wish to wear a sanitary napkin while using the vaginal cream to protect your clothing against stains. Continue using clotrimazole vaginal cream even if you get your period during treatment.

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.

Wash your hands before and after using this medication.

Insert the tablet, suppository, or cream into the vagina using the applicator as directed.

Use this medicine for the full prescribed length of time, even during your menstrual period. Your symptoms may improve before the infection is completely cleared. If the infection does not clear up, or if it appears to get worse, see your doctor.

Call your doctor if your symptoms do not improve after 3 days of treatment, or if they last longer than a week. Tell your doctor right away if you have a skin rash or hives, stomach pain, fever, chills, nausea, vomiting, or foul-smelling vaginal discharge.

You can use a sanitary napkin to prevent the medication from staining your clothing but do not use a tampon.

Store at room temperature away from moisture and heat.

You should not use clotrimazole vaginal if you are allergic to it.

If this is the first time you have ever had symptoms of a vaginal yeast infection, ask your doctor before using clotrimazole vaginal.

Tell your doctor if you have had more than 3 vaginal infections within 6 months. Frequent vaginal yeast infections that do not clear up with treatment may be a sign of a more serious condition.

Ask a doctor or pharmacist if it is safe for you to use clotrimazole vaginal if you have other medical conditions, especially:

• fever, chills, pain in your back or shoulder;

• stomach pain, vomiting;

• foul-smelling vaginal discharge;

• diabetes; or

• HIV or AIDS.

FDA pregnancy category B. Clotrimazole vaginal is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

Do not use clotrimazole vaginal without medical advice if you are breast-feeding a baby.

Do not give this medicine to a child younger than 12 years old without medical advice.

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

Unless your doctor tells you otherwise, continue your normal diet.

Do not have sexual intercourse. clotrimazole vaginal will not prevent the infection from spreading to your partner. Clotrimazole topical can also cause damage to a condom or a diaphragm. These forms of birth control may be less effective if you use them during treatment.

Avoid getting this medicine in your eyes, nose, or mouth.

Avoid wearing tight-fitting, synthetic clothing that doesn't allow air circulation. Wear clothing made of loose cotton and other natural fibers until the infection is healed.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have new or worsening vaginal symptoms.

Common side effects of clotrimazole vaginal may include:

• slight increase in vaginal discomfort (burning, itching, irritation).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Keep all appointments with your doctor.

Ask your pharmacist any questions you have about clotrimazole.

If you still have symptoms of infection 7 days after starting treatment with clotrimazole, call your doctor.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.