Conjupri is a calcium channel blocker that dilates (widens) blood vessels and improves blood flow.

Conjupri is used to treat high blood pressure (hypertension) in adults and children at least 6 years old. Lowering blood pressure may lower your risk of a stroke or heart attack.

Conjupri may also be used for purposes not listed in this medication guide.

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

You may take this medicine with or without food.

Your blood pressure will need to be checked often.

Your chest pain may become worse when you first start taking Conjupri or when your dose is increased. Call your doctor if your chest pain is severe or ongoing.

If you are being treated for high blood pressure, keep using Conjupri even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life.

Conjupri is only part of a complete program of treatment that may also include diet, exercise, weight control, and other medications. Follow your diet, medication, and exercise routines very closely.

Use all your blood pressure medications as directed and read all medication guides you receive. Do not change your dose or stop using a medicine without your doctor's advice.

Store at room temperature away from moisture, heat, and light.

You should not take Conjupri if you are allergic to Conjupri or amlodipine.

Tell your doctor if you have ever had:

• liver disease; or

• a heart valve problem called aortic stenosis.

Tell your doctor if you are pregnant or plan to become pregnant. It is not known whether Conjupri will harm an unborn baby. However, having high blood pressure during pregnancy may cause complications such as diabetes or eclampsia (dangerously high blood pressure that can lead to medical problems in both mother and baby). The benefit of treating hypertension may outweigh any risks to the baby.

Tell your doctor if you are breastfeeding.

Take the medicine as soon as you can, but skip the missed dose if you are more than 12 hours late for the dose. Do not take two doses at one time.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include rapid heartbeats, redness or warmth in your arms or legs, or fainting.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

In rare cases, when you first start taking Conjupri, your angina may get worse or you could have a heart attack. Seek emergency medical attention or call your doctor right away if you have symptoms such as: chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating.

Conjupri may cause serious side effects. Call your doctor at once if you have:

• pounding heartbeats or fluttering in your chest;

• worsening chest pain; or

• a light-headed feeling, like you might pass out.

Common side effects of Conjupri may include:

• fast heartbeats;

• swelling in your feet or ankles;

• dizziness, drowsiness;

• feeling tired;

• stomach pain, nausea; or

• flushing (warmth, redness, or tingly feeling).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Other drugs may affect Conjupri, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.