By using this site, you agree to the Privacy Policy and Terms of Use.
Accept
Medical Information, Documents, News - TheMediTary.Com Logo Medical Information, Documents, News - TheMediTary.Com Logo

TheMediTary.Com

Medical Information, Documents, News - TheMediTary.Com

  • Home
  • News
  • Drugs
  • Drugs A-Z
  • Medical Answers
  • About Us
  • Contact
Medical Information, Documents, News - TheMediTary.Com Logo Medical Information, Documents, News - TheMediTary.Com Logo
Search Drugs
  • Drugs
    • Latest Drugs
    • Drugs A-Z
    • Medical Answers
  • News
    • FDA Alerts
    • Medical News
    • Health
    • Consumer Updates
    • Children's Health
  • More TheMediTary.Com
    • About Us
    • Contact
Follow US
Home > Drugs > Alkylating agents > Dacarbazine
Alkylating agents

Dacarbazine

https://themeditary.com/drug/dacarbazine-4973.html
Medically Reviewed by Glamora Samuels, MD TheMediTary.Com | Reviewed: Aug 11, 2023  Additional Content by TheMediTary.Com

Generic name: dacarbazine [ da-kar-ba-zeen ]

Drug class: Alkylating agents

Dosage form: intravenous powder for injection (100 mg; 200 mg)

Availability: Prescription only

Pregnancy & Lactation: Risk data available

Contents
Uses Warnings Before Taking Dosage Side effects Interactions

What is Dacarbazine?

Dacarbazine is used to treat skin cancer (malignant melanoma) and Hodgkin's disease.

Dacarbazine may also be used for purposes not listed in this medication guide.

Warnings

Dacarbazine can increase your risk of bleeding or infection. Call your doctor if you have unusual bruising or bleeding, or new signs of infection (fever, weakness, cough, diarrhea, burning when you urinate).

How should I take Dacarbazine

Dacarbazine is given as an infusion into a vein. A healthcare provider will give you this injection.

To help prevent severe nausea or vomiting, avoid eating anything for 4 to 6 hours before your injection.

Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when dacarbazine is injected.

Dacarbazine is sometimes given daily for 5 to 10 days in a row every 3 or 4 weeks. For Hodgkin's disease, you may only receive dacarbazine for 1 day every 15 days. Your doctor will determine how long to treat you with dacarbazine.

Dacarbazine can increase your risk of bleeding or infection. You will need frequent medical tests. Your cancer treatments may be delayed based on the results.

Dosing information

Usual Adult Dose for Malignant Melanoma:

2 to 4.5 mg/kg IV once a day for 10 days; repeat every 4 weeks
OR
250 mg/m2 IV once a day for 5 days; repeat every 3 weeks

Use: For metastatic malignant melanoma

Usual Adult Dose for Hodgkin's Disease:

150 mg/m2 IV once a day for 5 days in combination therapy; repeat every 4 weeks
OR
375 mg/m2 IV on Day 1 in combination therapy; repeat every 15 days

Use: For Hodgkin's disease as a second-line therapy when used in combination with other agents

Detailed Dacarbazine dosage information
Dacarbazine Dosage information (more detail)

Before Taking

You should not use dacarbazine if you are allergic to it.

Tell your doctor if you have ever had:

  • liver disease;

  • a bleeding or blood clotting disorder; or

  • bone marrow suppression.

It is not known whether dacarbazine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

You should not breastfeed while using dacarbazine.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your dacarbazine injection.

What happens if I overdose?

Since dacarbazine is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What should I avoid while using Dacarbazine?

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

Do not receive a "live" vaccine while using dacarbazine. The vaccine may not work as well during this time, and may not fully protect you from disease. Live vaccines include measles, mumps, rubella (MMR), rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.

Dacarbazine side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Dacarbazine may cause serious side effects. Call your doctor at once if you have:

  • low blood cell counts--fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath; or

  • liver problems--loss of appetite, stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Common side effects of dacarbazine may include:

  • loss of appetite, nausea, vomiting.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See more: Dacarbazine Side Effects

What other drugs will affect Dacarbazine?

Other drugs may affect dacarbazine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

What other information should I know?

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

More about Dacarbazine (Dacarbazine [ da-kar-ba-zeen ])

Dosage information
Dacarbazine Side Effects
During pregnancy
Drug images
Side effects
Drug class: Alkylating agents

Related treatment guides

Hodgkin's Lymphoma
Melanoma, Metastatic
Melanoma
Share this Article
Contents
Uses Warnings Before Taking Dosage Side effects Interactions
Related Drugs
Fidanacogene Elaparvovec
Cerave Anti-Itch
Centrum Adult
Crovalimab
Cyltezo Prefilled Syringe
Zepbound Pen
Mylanta One
Uretron Ds
Medihoney Wound And Burn Dressing
Lidotrode

Other drugs

Name Drug Class Updated
Fidanacogene Elaparvovec Drugs 03-Oct-2024
Cerave Anti-Itch Drugs 02-Oct-2024
Centrum Adult Drugs 02-Oct-2024
Crovalimab Drugs 02-Oct-2024
Cyltezo Prefilled Syringe Drugs 01-Oct-2024
Zepbound Pen Drugs 30-Sep-2024
Mylanta One Drugs 27-Sep-2024
Uretron Ds Drugs 27-Sep-2024
Medihoney Wound And Burn Dressing Drugs 26-Sep-2024
Lidotrode Drugs 26-Sep-2024
Libervant Drugs 26-Sep-2024
Moderna Covid-19 Drugs 25-Sep-2024
Beqvez Drugs 24-Sep-2024
Beqvez Drugs 24-Sep-2024
Beqvez Drugs 24-Sep-2024

Categories

  • FDA Alerts
  • Medical News
  • Health
  • Consumer Updates
  • Children's Health

About US

Welcome to TheMediTary.Com

Our website provides reliable and up-to-date information on various medical topics. We empower individuals to take charge of their health by simplifying complex medical jargon and providing practical tips and advice. We prioritize the privacy and confidentiality of our users and welcome feedback to improve our services.

Website use data of FDA and other sources

DMCA.com Protection Status Truste Protection Status Trust Mark Protection Status
HONcode logo We comply with the HONcode standard for trustworthy health information.
Quick Link
  • About Us
  • Contact Us
  • Editorial Policy
  • Privacy Policy
  • Accessibility Policy
  • Terms & Conditions
  • Disclaimer
  • DMCA
  • Do Not Sell My Personal Information
  • Sitemap
  • Care Notes
  • Health Guide
  • Professional
Drugs
  • New Drugs
  • Medical Answers
  • Drugs A-Z
  • Drug Classes
  • Drug Dosage
  • Pill Identifier
  • Consumer Infor
  • Side Effects
  • Inactive Ingredients
  • Pregnancy Warnings
  • Patient Tips
  • Treatments
News
  • Latest News
  • FDA Alerts
  • Medical News
  • Health
  • Consumer Updates
  • Children's Health
Find US
  • Medium
  • Google Site
  • Blogspot
  • API
  • Reddit
  • Tumblr
  • Scoop.it
  • Substack
  • Wordpress
  • Wix
  • Behance

© 2025 TheMediTary.Com All rights reserved. Operated by