By using this site, you agree to the Privacy Policy and Terms of Use.
Accept
Medical Information, Documents, News - TheMediTary.Com Logo Medical Information, Documents, News - TheMediTary.Com Logo

TheMediTary.Com

Medical Information, Documents, News - TheMediTary.Com

  • Home
  • News
  • Drugs
  • Drugs A-Z
  • Medical Answers
  • About Us
  • Contact
Medical Information, Documents, News - TheMediTary.Com Logo Medical Information, Documents, News - TheMediTary.Com Logo
Search Drugs
  • Drugs
    • Latest Drugs
    • Drugs A-Z
    • Medical Answers
  • News
    • FDA Alerts
    • Medical News
    • Health
    • Consumer Updates
    • Children's Health
  • More TheMediTary.Com
    • About Us
    • Contact
Follow US
Home > Drugs > Miscellaneous coagulation modifiers > Defitelio
Miscellaneous coagulation modifiers

Defitelio

https://themeditary.com/drug/defitelio-1411.html
Medically Reviewed by Glamora Samuels, MD TheMediTary.Com | Reviewed: Jul 13, 2023  Additional Content by TheMediTary.Com

Generic name: defibrotide [ de-fye-broe-tide ]

Drug class: Miscellaneous coagulation modifiers

Dosage form: injection, solution

Availability: Prescription only

Pregnancy & Lactation: Risk data available

Brand names: Defibrotide

Contents
Uses Warnings Before Taking Dosage Side effects Interactions

What is Defitelio?

Defitelio works by increasing the breakdown of clots in the blood.

Defitelio is used to treat severe veno-occlusive disease (VOD) in adults and children who have undergone chemotherapy and a stem-cell transplant. VOD happens when blood vessels in the liver become blocked, which decreases blood flow and can lead to liver damage.

Defitelio may also be used for purposes not listed in this medication guide.

Warnings

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

How should I use Defitelio

Defitelio is injected into a vein through an IV. This medicine must be given slowly, and the IV infusion can last at least 2 hours.

You may be shown how to use an IV at home. Do not give yourself this medicine if you do not understand how to use the injection and properly dispose of needles, IV tubing, and other items used.

Defitelio is usually given for at least 21 days, to a maximum of 60 days if symptoms have not fully improved.

Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Defitelio must be mixed with a liquid (diluent) before using it. If you are using the injections at home, be sure you understand how to properly mix and store the medicine.

Do not mix Defitelio with other medicines in the same IV line. Follow your doctor's instructions about flushing your IV line after each injection.

Prepare your dose only when you are ready to give an injection. Do not use if the medicine has changed colors or has particles in it. Call your pharmacist for new medicine.

After mixing Defitelio with a diluent, store in the refrigerator and use within 24 hours.

Mixed medicine must be used within 4 hours if you keep it at room temperature.

Each single-use vial (bottle) of this medicine is for one use only. Throw away after one use, even if there is still some medicine left in it after injecting your dose.

Detailed Defitelio dosage information
Defitelio Dosage information (more detail)

Before Taking

You should not use Defitelio if you are allergic to it, or if:

  • you have active bleeding;

  • you also take a blood thinner such as warfarin (Coumadin, Jantoven); or

  • you use any medication to treat or dissolve blood clots such as streptokinase or urokinase.

To make sure Defitelio is safe for you, tell your doctor if you have:

  • a bleeding or blood clotting disorder.

It is not known whether Defitelio will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether defibrotide passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using Defitelio?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Defitelio side effects

Get emergency medical help if you have signs of an allergic reaction: hives, itching, skin rash; difficult breathing; swelling of your face, lips, tongue, or throat.

Defitelio may cause serious side effects. Call your doctor at once if you have:

  • easy bruising, unusual bleeding;

  • blood in your urine or stools;

  • confusion, headaches;

  • vision problems, slurred speech; or

  • a light-headed feeling, like you might pass out.

Your treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects of Defitelio may include:

  • nausea, vomiting, diarrhea;

  • dizziness; or

  • nosebleeds.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See more: Defitelio Side Effects

What other drugs will affect Defitelio?

Other drugs may interact with defibrotide, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

More about Defitelio (Defibrotide [ de-fye-broe-tide ])

Dosage information
Defitelio Side Effects
During pregnancy
Defitelio Prescribing Information
Drug images
Side effects
Drug class: Miscellaneous coagulation modifiers

Related treatment guides

Hepatic Veno-Occlusive Disease
Share this Article
Contents
Uses Warnings Before Taking Dosage Side effects Interactions
Related Drugs
Fidanacogene Elaparvovec
Cerave Anti-Itch
Centrum Adult
Crovalimab
Cyltezo Prefilled Syringe
Zepbound Pen
Mylanta One
Uretron Ds
Medihoney Wound And Burn Dressing
Lidotrode

Other drugs

Name Drug Class Updated
Fidanacogene Elaparvovec Drugs 03-Oct-2024
Cerave Anti-Itch Drugs 02-Oct-2024
Centrum Adult Drugs 02-Oct-2024
Crovalimab Drugs 02-Oct-2024
Cyltezo Prefilled Syringe Drugs 01-Oct-2024
Zepbound Pen Drugs 30-Sep-2024
Mylanta One Drugs 27-Sep-2024
Uretron Ds Drugs 27-Sep-2024
Medihoney Wound And Burn Dressing Drugs 26-Sep-2024
Lidotrode Drugs 26-Sep-2024
Libervant Drugs 26-Sep-2024
Moderna Covid-19 Drugs 25-Sep-2024
Beqvez Drugs 24-Sep-2024
Beqvez Drugs 24-Sep-2024
Beqvez Drugs 24-Sep-2024

Categories

  • FDA Alerts
  • Medical News
  • Health
  • Consumer Updates
  • Children's Health

About US

Welcome to TheMediTary.Com

Our website provides reliable and up-to-date information on various medical topics. We empower individuals to take charge of their health by simplifying complex medical jargon and providing practical tips and advice. We prioritize the privacy and confidentiality of our users and welcome feedback to improve our services.

Website use data of FDA and other sources

DMCA.com Protection Status Truste Protection Status Trust Mark Protection Status
HONcode logo We comply with the HONcode standard for trustworthy health information.
Quick Link
  • About Us
  • Contact Us
  • Editorial Policy
  • Privacy Policy
  • Accessibility Policy
  • Terms & Conditions
  • Disclaimer
  • DMCA
  • Do Not Sell My Personal Information
  • Sitemap
  • Care Notes
  • Health Guide
  • Professional
Drugs
  • New Drugs
  • Medical Answers
  • Drugs A-Z
  • Drug Classes
  • Drug Dosage
  • Pill Identifier
  • Consumer Infor
  • Side Effects
  • Inactive Ingredients
  • Pregnancy Warnings
  • Patient Tips
  • Treatments
News
  • Latest News
  • FDA Alerts
  • Medical News
  • Health
  • Consumer Updates
  • Children's Health
Find US
  • Medium
  • Google Site
  • Blogspot
  • API
  • Reddit
  • Tumblr
  • Scoop.it
  • Substack
  • Wordpress
  • Wix
  • Behance

© 2025 TheMediTary.Com All rights reserved. Operated by