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Home > Drugs > Dopaminergic antiparkinsonism agents > Entacapone
Dopaminergic antiparkinsonism agents

Entacapone

https://themeditary.com/drug/entacapone-7987.html
Medically Reviewed by Glamora Samuels, MD TheMediTary.Com | Reviewed: Aug 16, 2023  Additional Content by TheMediTary.Com

Generic name: entacapone [ en-tak-a-pone ]

Drug class: Dopaminergic antiparkinsonism agents

Dosage form: oral tablet (200 mg)

Availability: Prescription only

Pregnancy & Lactation: Risk data available

Brand names: Comtan

Contents
Uses Warnings Before Taking Dosage Side effects Interactions
  • Entacapone (Entacapone [ en-tak-a-pone ])-W 781-200 mg-Orange-Oval Entacapone 200 mg (W 781)
  • Entacapone (Entacapone [ en-tak-a-pone ])-W711-200 mg-Orange-Oval Entacapone 200 mg (W711)
  • Entacapone (Entacapone [ en-tak-a-pone ])-T2 200-200 mg-Orange-Oval Entacapone 200 mg (T2 200)
  • Entacapone (Entacapone [ en-tak-a-pone ])-EN1 200-200 mg-Orange-Oval Entacapone 200 mg (EN1 200)
  • View all images

What is Entacapone?

When used with carbidopa and levodopa (Atamet, Parcopa, Sinemet), entacapone increases levels of levodopa in the body.

Entacapone is used together with carbidopa and levodopa to treat "wearing-off" symptoms of Parkinson's disease, such as stiffness, tremors, muscle spasms, and poor muscle control.

Entacapone may also be used for purposes not listed in this medication guide.

Warnings

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

How should I take Entacapone

Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Entacapone must be taken together with carbidopa and levodopa. Entacapone used alone will not treat symptoms of Parkinson's disease.

Entacapone can be taken with or without food. Taking the medicine with food may help prevent nausea, which is a common side effect of entacapone.

Drink plenty of liquids while you are taking entacapone.

Entacapone may cause you to fall asleep during normal daytime activities such as working, talking, eating, or driving. You may fall asleep suddenly, even after feeling alert. Tell your doctor if you have any problems with daytime sleepiness or drowsiness.

Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking this medicine, which can lead to severely low blood pressure or a serious electrolyte imbalance.

You should not stop using entacapone suddenly. Follow your doctor's instructions about tapering your dose.

Store at room temperature away from moisture and heat.

Dosing information

Usual Adult Dose for Parkinson's Disease:

200 mg orally concomitantly with each dose of levodopa-carbidopa up to a maximum of 8 times a day
Maximum dose: 1600 mg per day

Comments:
-Upon initiation, a majority of patients required levodopa dose reductions or an extension of the interval between their levodopa doses, especially those receiving levodopa doses of 800 mg/day or greater, and patients with baseline moderate or severe dyskinesia.

Use: As an adjunct to levodopa-carbidopa to treat end-of-dose "wearing-off" in patients with Parkinson's disease.

Detailed Entacapone dosage information
Entacapone Dosage information (more detail)

Before Taking

You should not use entacapone if you are allergic to it.

To make sure entacapone is safe for you, tell your doctor if you have:

  • low blood pressure;

  • liver disease; or

  • a history of mental illness or psychosis.

You may have increased sexual urges, unusual urges to gamble, or other intense urges while taking entacapone. Talk with your doctor if this occurs.

People with Parkinson's disease may have a higher risk of skin cancer (melanoma). Talk to your doctor about this risk and what skin symptoms to watch for. You may need to have regular skin exams.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether entacapone passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include agitation and aggression, or severe drowsiness, confusion, and loss of consciousness.

What should I know about storage and disposal of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

What should I avoid while using Entacapone?

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Entacapone may cause you to fall asleep suddenly, even after feeling alert.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Avoid drinking alcohol. It can increase some of the side effects of entacapone.

Entacapone side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Entacapone may cause serious side effects. Call your doctor at once if you have:

  • agitation, confusion, unusual thoughts or behavior;

  • hallucinations (hearing or seeing something that is not there);

  • very stiff (rigid) muscles, high fever, sweating, fast or uneven heartbeats, tremors, feeling like you might pass out;

  • severe or ongoing diarrhea;

  • restless muscle movements in your eyes, tongue, jaw, or neck (or worsening of Parkinson symptoms); or

  • unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.

You may notice that your urine appears orange, red, brown, or black in color. This is not a harmful side effect unless you also have muscle pain and unusual weakness.

Common side effects of entacapone may include:

  • dizziness, drowsiness;

  • nausea, vomiting, stomach pain;

  • diarrhea;

  • dry mouth; or

  • uncontrolled muscle movements.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See more: Entacapone Side Effects

What other drugs will affect Entacapone?

Taking entacapone with other drugs that make you sleepy can worsen this effect. Ask your doctor before taking entacapone with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.

Tell your doctor about all medicines you use, and those you start or stop using during your treatment with entacapone, especially:

  • isocarboxazid;

  • linezolid;

  • methylene blue injection;

  • phenelzine; or

  • tranylcypromine.

This list is not complete. Other drugs may interact with entacapone, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

What other information should I know?

Keep all appointments with your doctor and the laboratory. You may become dizzy when you get up after sitting or lying down, especially when you begin taking entacapone. To avoid this problem, make sure to get up slowly, especially if you have been sitting or lying down for a long time.

Entacapone may cause your urine to change to a brownish-orange color. This effect is common and is not harmful.

Do not let anyone else take your medicine. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Combination Products

  • Stalevo® (containing Carbidopa, Entacapone, Levodopa)

More about Entacapone (Entacapone [ en-tak-a-pone ])

Dosage information
Entacapone Side Effects
During pregnancy
Drug images
Side effects
Breastfeeding Warnings
Drug class: Dopaminergic antiparkinsonism agents

Related treatment guides

Parkinson's Disease
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