You should not use esterified estrogens and methyltestosterone if you have:
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unusual vaginal bleeding that has not been checked by a doctor;
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severe liver disease;
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if you have had a stroke or blood clot;
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if you have had hormone-related cancer, or cancer of the breast, uterus/cervix, or vagina; or
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if you are pregnant or breastfeeding.
Do not use this medicine if you are pregnant. Tell your doctor right away if you become pregnant during treatment.
Using this medicine can increase your risk of blood clots, stroke, or heart attack. You are even more at risk if you have high blood pressure, diabetes, high cholesterol, if you are overweight, or if you smoke.
Esterified estrogens and methyltestosterone should not be used to prevent heart disease or stroke because this medicine may actually increase your risk of developing these conditions.
Tell your doctor if you have ever had:
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heart disease;
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liver problems, or jaundice caused by pregnancy or taking hormones;
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a thyroid disorder;
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gallbladder disease;
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kidney disease;
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asthma;
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epilepsy or other seizure disorder;
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migraine headaches;
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diabetes;
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depression;
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uterine fibroid tumors;
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a breast lump or abnormal mammogram; or
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porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system).
Using this medicine may increase your risk of cancer of the breast, uterus, vagina, or liver. Talk with your doctor about this risk.
It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.