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Home > Drugs > Opioids (narcotic analgesics) > Fentanyl (buccal/sublingual)
Opioids (narcotic analgesics)

Fentanyl (buccal/sublingual)

https://themeditary.com/drug/fentanyl-buccal-sublingual-6745.html
Medically Reviewed by Glamora Samuels, MD TheMediTary.Com | Reviewed: Aug 14, 2023  Additional Content by TheMediTary.Com

Generic name: fentanyl (buccal/sublingual) [ fen-tan-il-buk-al-/ sub-lin-gwal ]

Drug class: Opioids (narcotic analgesics)

Availability: Prescription only

Pregnancy & Lactation: Risk data available

Brand names: Fentanyl, Duragesic skin patch, Duragesic-100 (skin patch), Fentora, Ionsys

Contents
Uses Warnings Before Taking Dosage Side effects Interactions FAQ
  • Fentanyl (buccal/sublingual) (Fentanyl (buccal/sublingual) [ fen-tan-il-buk-al-/ sub-lin-gwal ])-C 1-100 mcg-White-Round Fentanyl (buccal/sublingual) 100 mcg (C 1)
  • Fentanyl (buccal/sublingual) (Fentanyl (buccal/sublingual) [ fen-tan-il-buk-al-/ sub-lin-gwal ])-C 2-200 mcg-White-Round Fentanyl (buccal/sublingual) 200 mcg (C 2)
  • Fentanyl (buccal/sublingual) (Fentanyl (buccal/sublingual) [ fen-tan-il-buk-al-/ sub-lin-gwal ])-C 4-400 mcg-White-Round Fentanyl (buccal/sublingual) 400 mcg (C 4)
  • Fentanyl (buccal/sublingual) (Fentanyl (buccal/sublingual) [ fen-tan-il-buk-al-/ sub-lin-gwal ])-C 6-600 mcg-White-Round Fentanyl (buccal/sublingual) 600 mcg (C 6)
  • View all images

What is Fentanyl (buccal/sublingual)?

Fentanyl buccal or sublingual products are used in the mouth but not swallowed whole. Fentanyl buccal is placed inside the mouth between the cheek and gum. Fentanyl sublingual is placed under the tongue.

Fentanyl buccal/sublingual is an opioid pain medicine used to treat "breakthrough" cancer pain that is not controlled by other medicines. fentanyl is not for treating pain that is not cancer-related.

Fentanyl buccal/sublingual may also be used for purposes not listed in this medication guide.

Warnings

MISUSE OF OPIOID MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it.

Do not use fentanyl unless you are already using an around-the-clock opioid medicine and are tolerant to it.

Taking opioid medicine during pregnancy may cause life-threatening withdrawal symptoms in the newborn.

Fatal side effects can occur if you use opioid medicine with alcohol, or with other drugs that cause drowsiness or slow your breathing.

How should I use Fentanyl (buccal/sublingual)

If you have been using another form of fentanyl (injection, skin patch, "lollipop" device), your buccal or sublingual dose may be different.

Follow the directions on your prescription label and read all medication guides. Never use fentanyl in larger amounts, or for longer than prescribed. Tell your doctor if you feel an increased urge to take more of fentanyl.

Never share opioid medicine with another person, especially someone with a history of drug abuse or addiction. MISUSE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH. Keep the medication in a place where others cannot get to it. Selling or giving away opioid medicine is against the law.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

Call your doctor if you have breakthrough pain more than 4 times in one day while using this medicine. Do not treat more than 4 pain episodes per day with this medicine.

Do not stop using fentanyl suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using fentanyl.

Never crush or break a fentanyl pill to inhale the powder or mix it into a liquid to inject the drug into your vein.

Store at room temperature away from moisture and heat. Do not freeze. Keep track of your medicine. You should be aware if anyone is using it improperly or without a prescription.

Keep this medicine out of the reach of children or pets. The amount of fentanyl in each buccal or sublingual product can be fatal to a child or pet who accidentally sucks on or swallows it. Seek emergency medical attention if this happens.

Do not keep leftover opioid medication. Just one dose can cause death in someone using this medicine accidentally or improperly. Ask your pharmacist where to locate a drug take-back disposal program. If there is no take-back program, throw away any unused fentanyl tablets by removing them from the blister pack and flushing them down a toilet. Dispose of used sublingual spray units in the disposal bags provided with the medicine. Empty any unused spray units into the disposal bottle provided.

Detailed Fentanyl dosage information
Fentanyl (buccal/sublingual) Dosage information (more detail)

Before Taking

Do not use fentanyl unless you are already using an around-the-clock opioid medicine and are tolerant to it. You should not use fentanyl if you are allergic to it, or if you have:

  • severe asthma or other breathing problems; or

  • a stomach or bowel obstruction (including paralytic ileus).

Tell your doctor if you have ever had:

  • breathing problems, sleep apnea;

  • a head injury, or seizures;

  • low blood pressure, slow heartbeats or other heart rhythm disorder;

  • drug or alcohol addiction, depression, schizophrenia, or hallucinations;

  • liver or kidney disease;

  • urination problems; or

  • problems with your thyroid, gallbladder, or pancreas.

Tell your doctor if there are children living in the home where you will store this medicine. The amount of fentanyl in this medicine can be fatal to a child.

If you use opioid medicine while you are pregnant, your baby could become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on opioids may need medical treatment for several weeks.

Do not breast-feed while you are using this medicine.

What happens if I miss a dose?

Since fentanyl is used for pain, you are not likely to miss a dose. Skip any missed dose if it is almost time for your next dose. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A fentanyl overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include extreme weakness or drowsiness, weak pulse, cold and clammy skin, pinpoint pupils, and slow breathing (breathing may stop).

What should I avoid while using Fentanyl (buccal/sublingual)?

Avoid driving or hazardous activity until you know how fentanyl will affect you. Dizziness or drowsiness can cause falls, accidents, or severe injuries.

Do not drink alcohol. Dangerous side effects or death could occur.

Grapefruit may interact with fentanyl and lead to unwanted side effects. Avoid the use of grapefruit products.

Fentanyl (buccal/sublingual) side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Opioid medicine can slow or stop your breathing, and death may occur. A person caring for you should seek emergency medical attention if you have slow breathing with long pauses, blue colored lips, or if you are hard to wake up.

Fentanyl may cause serious side effects. Call your doctor at once if you have:

  • slow heart rate, sighing, shallow breathing, breathing that stops during sleep;

  • severe drowsiness, feeling like you might pass out;

  • confusion, extreme fear, unusual thoughts or behavior; or

  • low cortisol levels--nausea, vomiting, loss of appetite, dizziness, worsening tiredness or weakness.

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Serious side effects may be more likely in older adults and those who are malnourished or debilitated.

Long-term use of opioid medication may affect fertility (ability to have children) in men or women. It is not known whether opioid effects on fertility are permanent.

Common side effects of fentanyl may include:

  • headache, dizziness, drowsiness, pale skin, feeling weak or tired;

  • constipation, nausea, vomiting; or

  • swelling in your hands or feet.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See more: Fentanyl (buccal/sublingual) Side Effects

What other drugs will affect Fentanyl (buccal/sublingual)?

You may have breathing problems or withdrawal symptoms if you start or stop taking certain other medicines. Tell your doctor if you also use an antibiotic, antifungal medication, heart or blood pressure medication, seizure medication, or medicine to treat HIV or hepatitis C.

Opioid medication can interact with many other drugs and cause dangerous side effects or death. Be sure your doctor knows if you also use:

  • cold or allergy medicines, bronchodilator asthma/COPD medication, or a diuretic ("water pill");

  • medicines for motion sickness, irritable bowel syndrome, or overactive bladder;

  • other narcotic medications--opioid pain medicine or prescription cough medicine;

  • a sedative like Valium--diazepam, alprazolam, lorazepam, Xanax, Klonopin, Versed, and others;

  • drugs that make you sleepy or slow your breathing--a sleeping pill, muscle relaxer, medicine to treat mood disorders or mental illness; or

  • drugs that affect serotonin levels in your body--a stimulant, or medicine for depression, Parkinson's disease, migraine headaches, serious infections, or nausea and vomiting.

This list is not complete. Other drugs may affect fentanyl, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here.

More FAQ

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More about Fentanyl (buccal/sublingual) (Fentanyl (buccal/sublingual) [ fen-tan-il-buk-al-/ sub-lin-gwal ])

Dosage information
Fentanyl (buccal/sublingual) Side Effects
During pregnancy
Drug images
Side effects
Breastfeeding Warnings
Drug class: Opioids (narcotic analgesics)

Related treatment guides

Chronic Pain
Anesthesia
Anesthetic Adjunct
Breakthrough Pain
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