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Home > Drugs > Serotonin-norepinephrine reuptake inhibitors > Fetzima
Serotonin-norepinephrine reuptake inhibitors

Fetzima

https://themeditary.com/drug/fetzima-279.html
Medically Reviewed by Oluni Odunlami, MD TheMediTary.Com | Reviewed: Jul 10, 2023  Additional Content by TheMediTary.Com

Generic name: levomilnacipran [ lee-voe-mil-na-si-pran ]

Drug class: Serotonin-norepinephrine reuptake inhibitors

Dosage form: capsule, extended release

Availability: Prescription only

Pregnancy & Lactation: Risk data available

Brand names: Levomilnacipran

Contents
Uses Warnings Before Taking Dosage Side effects Interactions FAQ
  • Fetzima (Levomilnacipran [ lee-voe-mil-na-si-pran ])-FL 20-20 mg-Yellow & White-Capsule-shape Fetzima 20 mg (FL 20)
  • Fetzima (Levomilnacipran [ lee-voe-mil-na-si-pran ])-FL 40-40 mg-Yellow-Capsule-shape Fetzima 40 mg (FL 40)
  • Fetzima (Levomilnacipran [ lee-voe-mil-na-si-pran ])-FL 80-80 mg-Pink & White-Capsule-shape Fetzima 80 mg (FL 80)
  • Fetzima (Levomilnacipran [ lee-voe-mil-na-si-pran ])-FL 120-120 mg-Pink-Capsule-shape Fetzima 120 mg (FL 120)
  • View all images

What is Fetzima?

Fetzima is a selective serotonin and norepinephrine reuptake inhibitor antidepressant (SNRI). Levomilnacipran affects chemicals in the brain that may be unbalanced in people with depression.

Fetzima extended release capsules are used to treat major depressive disorder.

A similar medicine called milnacipran (Savella) is used to treat a chronic pain disorder called fibromyalgia. Fetzima should not be used to treat fibromyalgia.

Warnings

You should not use Fetzima if you have untreated or uncontrolled narrow-angle glaucoma.

Do not use Fetzima within 7 days before or 14 days after you have taken an MAO inhibitor, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, and tranylcypromine.

People with depression or mental illness may have thoughts about suicide. Some young people may have increased suicidal thoughts when first starting a medicine to treat depression. Tell your doctor right away if you have any sudden changes in mood or behavior, or thoughts about suicide.

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Do not stop using Fetzima without first asking your doctor.

Fetzima is not approved for use by anyone younger than 18 years old.

How should I take Fetzima

Take Fetzima exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.

Take Fetzima at the same time each day, with or without food.

Swallow the Fetzima extended release capsule whole and do not crush, chew, break, or open it.

Your blood pressure and heart rate will need to be checked often.

Tell your doctor if you have any changes in sexual function, such as loss of interest in sex, trouble having an orgasm, or (in men) problems with erections or ejaculation. Some sexual problems can be treated.

Do not stop using Fetzima suddenly, or you could have unpleasant symptoms (such as agitation, confusion, tingling or electric shock feelings). Ask your doctor before stopping the medicine.

Store at room temperature away from moisture and heat.

Dosing information

Usual Adult Dose for Depression:

Initial dose: 20 mg orally once a day for 2 days, then increase to 40 mg orally once a day
Maintenance dose: 40 to 120 mg orally once a day
Maximum dose: 120 mg/day

Comments:
-The dose may be increased in increments of 40 mg at intervals of 2 or more days based on tolerability and efficacy.
-Efficacy was established in trials lasting 5 weeks.

Use: Treatment of Major Depressive Disorder (MDD)

Detailed Fetzima dosage information
Fetzima Dosage information (more detail)

Before Taking

You should not use Fetzima if you are allergic to levomilnacipran or milnacipran (Savella).

Do not use Fetzima within 7 days before or 14 days after you have taken an MAO inhibitor. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, tranylcypromine, and others.

Tell your doctor if you also use stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. An interaction with levomilnacipran could cause a serious condition called serotonin syndrome.

To make sure Fetzima is safe for you, tell your doctor if you have ever had:

  • glaucoma;

  • heart problems, high blood pressure;

  • a stroke;

  • bleeding problems;

  • urination problems;

  • sexual problems;

  • kidney disease;

  • a seizure;

  • low levels of sodium in your blood;

  • bipolar disorder (manic depression);

  • if there is a history of depression, manic behavior, or suicide in your family; or

  • if you drink alcohol.

People with depression or mental illness may have thoughts about suicide. Some young people may have increased suicidal thoughts when first starting a medicine to treat depression. Stay alert to changes in your mood or symptoms. Your family or caregivers should also watch for sudden changes in your behavior.

Ask your doctor about taking this medicine if you are pregnant. Taking an SNRI antidepressant during late pregnancy could increase your risk of excessive bleeding just after you give birth, and may cause serious medical complications in the baby. However, you may have a relapse of depression if you stop taking your antidepressant. Tell your doctor right away if you become pregnant. Do not start or stop taking this medicine without your doctor's advice.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of levomilnacipran on the baby.

If you are breastfeeding while taking Fetzima, tell your doctor if your baby is agitated or irritable and has feeding problems or trouble gaining weight.

Fetzima is not approved for use by anyone younger than 18 years old.

Fetzima pregnancy and breastfeeding warnings (more detail)

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using Fetzima?

Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.

Ask your doctor before taking a nonsteroidal anti-inflammatory drug (NSAID) such as aspirin, ibuprofen, naproxen, Advil, Aleve, Motrin, and others. Using an NSAID with levomilnacipran may cause you to bruise or bleed easily.

Avoid drinking alcohol. It may raise your blood levels of levomilnacipran.

Fetzima side effects

Get emergency medical help if you have signs of an allergic reaction to Fetzima: skin rash or hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your doctor right away if you have new or sudden changes in mood or behavior, including new or worse depression or anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, more active or talkative, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have:

  • blurred vision, tunnel vision, eye pain or swelling, eye redness;

  • painful or difficult urination;

  • easy bruising, unusual bleeding, purple or red spots under your skin;

  • pounding heartbeats or fluttering in your chest;

  • seizure (convulsions);

  • manic episodes - racing thoughts, increased energy, decreased need for sleep, risk-taking behavior, being agitated or talkative; or

  • low sodium level - headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady.

Serious side effects may be more likely in older adults.

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Common Fetzima side effects may include:

  • nausea, vomiting, constipation;

  • irregular heartbeats;

  • sweating; or

  • decreased sex drive, impotence, or difficulty having an orgasm.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See more: Fetzima Side Effects

What other drugs will affect Fetzima?

Using Fetzima with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.

Tell your doctor about all your other medicines, especially:

  • any other antidepressant;

  • sibutramine;

  • St. John's wort;

  • tryptophan (sometimes called L-tryptophan);

  • a diuretic or "water pill";

  • a blood thinner (warfarin, Coumadin, Jantoven);

  • diet pills, stimulants, or medicine to treat attention deficit hyperactivity disorder (ADHD) such as Adderall or Ritalin;

  • pain medication - fentanyl, tramadol;

  • medicine to treat anxiety, mood disorders, thought disorders, or mental illness - buspirone, lithium, and many others; or

  • migraine headache medicine - sumatriptan, rizatriptan, zolmitriptan, and others.

This list is not complete. Other drugs may interact with levomilnacipran, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Popular FAQ

Does Fetzima cause hair loss?
How long does it take Fetzima to leave your system?
Does Fetzima help with anxiety?
Does Fetzima cause weight loss or weight gain?

More FAQ

I have been off of Fetzima for a month and the sweating has continued. I have no quality of life?
How long does Fetzima withdrawal last?
Has anyone had really bad withdrawal from the fetzima?
View more FAQ

More about Fetzima (Levomilnacipran [ lee-voe-mil-na-si-pran ])

Dosage information
Fetzima Side Effects
During pregnancy
Fetzima Prescribing Information
Drug images
Side effects
Drug class: Serotonin-norepinephrine reuptake inhibitors

Patient resources

Fetzima Titration

Related treatment guides

Major Depressive Disorder
Depression
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Contents
Uses Warnings Before Taking Dosage Side effects Interactions FAQ
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