Generic name: zirgan
Availability: Prescription only
Pregnancy & Lactation: Risk data available
Brand names: Zirgan, Ganciclovir ophthalmic
What is Ganciclovir (monograph)?
Introduction
Antiviral; purine nucleoside analog of guanine.
Uses for Ganciclovir
Herpetic Keratitis
Topical treatment of acute herpetic keratitis in patients with dendritic ulcers; designated an orphan drug by FDA for treatment of acute herpetic keratitis (dendritic and geographic† [off-label] ulcers).
Herpetic keratitis usually caused by herpes simplex virus (HSV) type 1 (HSV-1), but can be caused by HSV type 2 (HSV-2).
Ganciclovir Dosage and Administration
Administration
Ophthalmic Administration
Apply 0.15% ophthalmic gel topically to the eye.
To avoid contaminating the ophthalmic gel, do not allow tip of dispensing dropper to touch any surface.
Dosage
Pediatric Patients
Herpetic Keratitis
Ophthalmic
Children ≥2 years of age with dendritic ulcers: Instill 1 drop of 0.15% ophthalmic gel into affected eye 5 times daily (approximately every 3 hours while awake) until corneal ulcer heals. Then, instill 1 drop 3 times daily for 7 additional days.
Children ≥2 years of age with geographic ulcers† [off-label]: Some experts state use same dosage recommended for dendritic ulcers.
Adults
Herpetic Keratitis
Ophthalmic
Dendritic ulcers: Instill 1 drop of 0.15% ophthalmic gel into affected eye 5 times daily (approximately every 3 hours while awake) until corneal ulcer heals. Then, instill 1 drop 3 times daily for 7 additional days.
Geographic ulcers† [off-label]: Some experts state use same dosage recommended for dendritic ulcers.
Special Populations
No special population dosage recommendations.
Warnings
Contraindications
-
Manufacturer states none.
Warnings/Precautions
Administration Precautions
For topical ophthalmic use only.
Do not wear contact lenses during topical treatment with ganciclovir gel or if any signs or symptoms of herpetic keratitis are present.
Specific Populations
Pregnancy
Category C.
Use only if potential benefits to the woman justify risks to the fetus.
No adequate, well-controlled studies in pregnant women; IV ganciclovir associated with embryotoxicity, teratogenicity, and/or maternal toxicity in animal studies.
Lactation
Not known whether distributed into milk after topical application to the eye.
Use with caution in nursing women.
Pediatric Use
Safety and efficacy not established in children <2 years of age.
Geriatric Use
No overall differences in safety or efficacy observed between geriatric and younger patients.
Common Adverse Effects
Blurred vision, eye irritation, punctate keratitis, conjunctival hyperemia.
How should I use Ganciclovir (monograph)
Administration
Ophthalmic Administration
Apply 0.15% ophthalmic gel topically to the eye.
To avoid contaminating the ophthalmic gel, do not allow tip of dispensing dropper to touch any surface.
Dosage
Pediatric Patients
Herpetic Keratitis
Ophthalmic
Children ≥2 years of age with dendritic ulcers: Instill 1 drop of 0.15% ophthalmic gel into affected eye 5 times daily (approximately every 3 hours while awake) until corneal ulcer heals. Then, instill 1 drop 3 times daily for 7 additional days.
Children ≥2 years of age with geographic ulcers† [off-label]: Some experts state use same dosage recommended for dendritic ulcers.
Adults
Herpetic Keratitis
Ophthalmic
Dendritic ulcers: Instill 1 drop of 0.15% ophthalmic gel into affected eye 5 times daily (approximately every 3 hours while awake) until corneal ulcer heals. Then, instill 1 drop 3 times daily for 7 additional days.
Geographic ulcers† [off-label]: Some experts state use same dosage recommended for dendritic ulcers.
Special Populations
No special population dosage recommendations.