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Home > Drugs > MTOR inhibitors > Hyftor
MTOR inhibitors

Hyftor

https://themeditary.com/drug/hyftor-2009.html
Medically Reviewed by Judith Stewart, BPharm TheMediTary.Com | Reviewed: Jul 13, 2023  Additional Content by TheMediTary.Com

Generic name: sirolimus

Drug class: MTOR inhibitors, Selective immunosuppressants

Dosage form:  topical gel

Availability: Prescription only

Pregnancy & Lactation: Risk data available

Brand names: Sirolimus topical

Contents
Uses Warnings Before Taking Dosage Side effects Interactions

What is Hyftor?

Hyftor is a prescription medicine that is used on the skin (topical) to treat adults and children 6 years of age and older with a type of noncancerous tumor called angiofibroma on your face caused by the genetic condition tuberous sclerosis.

It is not known if this medicine is safe and effective in children under 6 years of age.

Do not use Hyftor if you are allergic to sirolimus or any of the other ingredients. See the end of this page for a complete list of ingredients.

Important: Hyftor is for use on the skin only (topical use). Do not use the gel in your mouth, eyes, or vagina.

How should I take Hyftor

  • Use Hyftor gel exactly as your healthcare provider tells you to use it.
  • Before you use the gel, your healthcare provider or pharmacist should show you how to correctly measure your dose.
  • Wash your hands before and after applying the gel.
  • Apply Hyftor to the skin of the face affected with angiofibroma 2 times a day, in the morning and at bedtime.
  • Do not cover, wrap, apply dressings, or bandage the skin area treated with Hyftor.
  • Tell your healthcare provider if the treated skin area does not improve within 12 weeks of treatment.

Dosing information

Usual Adult Dose for Facial Angiofibroma Associated with Tuberous Sclerosis

- Apply to the skin of the face affected with angiofibroma twice daily.
The maximum daily dosage is 800 mg (2.5 cm) for patients 12 years of age and older.

Usual Pediatric Dose for Facial Angiofibroma Associated with Tuberous Sclerosis

-Apply to the skin of the face affected with angiofibroma twice daily.
The maximum daily dosage is 600 mg (2 cm) for patients 6 to 11 years of age.

Detailed Hyftor dosage information
Hyftor Dosage information (more detail)

Before Taking

Before you start treatment, tell your healthcare provider about all of your medical conditions, including if you:

  • have a skin infection at the treatment site
  • have high cholesterol or high triglycerides (fat or lipids) in your blood
  • are scheduled to receive an immunization (vaccine). You should avoid receiving live vaccines during treatment with Hyftor. Vaccines may be less effective.
  • are pregnant or plan to become pregnant. Hyftor may harm your unborn baby. You should not become pregnant during treatment.
    • Females who are able to become pregnant should use effective birth control (contraception) before starting, during treatment, and for 12 weeks after your final dose. Talk to your healthcare provider about types of birth control that you can use during this time.
  • are breastfeeding or plan to breastfeed. It is not known if Hyftor passes into your breast milk. You should not breastfeed during treatment.
Hyftor pregnancy and breastfeeding warnings (more detail)

Related/similar drugs

Epidiolex, cannabidiol, sirolimus topical, everolimus, Afinitor, Afinitor Disperz

What should I avoid while using Hyftor?

Limit your exposure to sunlight and ultraviolet light, such as tanning beds and ultraviolet light therapy, during treatment. Wear clothing that covers your skin if you need to go outside. Talk with your healthcare provider about other ways you can protect your skin from the sun.

Hyftor side effects

Hyftor may cause serious side effects, including:

  • Allergic reactions. Serious allergic reactions have happened in people who have taken sirolimus by mouth. Stop using Hyftor and get medical help right away if you get any of these symptoms of a serious allergic reaction:
    • swelling of your face, eyes, or mouth
    • chest pain or tightness
    • trouble breathing or wheezing
    • feeling dizzy or faint
    • throat tightness
    • rash or peeling of your skin
  • Infections. Serious infections, including infections that can happen when your immune system is weak, have happened in people who have taken sirolimus by mouth. Some people have developed a rare, serious brain infection called progressive multifocal leukoencephalopathy (PML) which can sometimes cause death. Stop treatment and call your healthcare provider right away if you get symptoms of an infection including fever or chills.
  • Risk of cancer. Lymphoma and other cancers, especially skin cancer, have happened in people who have taken sirolimus by mouth. Talk with your healthcare provider about your risk for cancer if you use Hyftor.
  • Increased levels of cholesterol and triglycerides (fat or lipids) in the blood have happened in people who have taken sirolimus by mouth. Your healthcare provider may do blood tests to check you for high lipid levels during treatment with Hyftor and treat you, if needed.
  • Lung or breathing problems. Lung or breathing problems, including problems that have sometimes caused death, have happened in people who have taken sirolimus by mouth. Stop treatment and get medical help right away if you get symptoms such as shortness of breath, new or worsening cough, or chest pain.

The most common side effects include dry skin, application site irritation, itching, acne, acne-like rash, eye redness, skin bleeding, and skin irritation. Hyftor may cause fertility problems in males and females, which may affect your ability to have children. Talk to your healthcare provider if this is a concern for you.

These are not all the possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See more: Hyftor Side Effects

What other drugs will affect Hyftor?

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Using Hyftor with certain medicines may affect each other causing side effects.

More about Hyftor (Sirolimus)

Dosage information
Hyftor Side Effects
During pregnancy
Hyftor Prescribing Information
Drug images
Side effects
Drug class: MTOR inhibitors

Related treatment guides

Tuberous Sclerosis Complex
Angiofibroma
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Contents
Uses Warnings Before Taking Dosage Side effects Interactions
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