Izervay (avacincaptad pegol) is used for treating geographic atrophy (GA),  due to age-related macular degeneration (AMD). Geographic atrophy can lead to irreversible vision loss. Izervay aims to slow down the progression of geographic atrophy, so your vision does not deteriorate as rapidly,  allowing you to maintain better vision for a longer period of time. Izervay is given as an intravitreal injection; this is when medication is injected directly into the vitreous humor in the eye. 

Izervay is the brand name for avacincaptad pegol.

Izervay is given by a qualified physician as an intravitreal injection; this is when medication is injected directly into the vitreous humor in the eye. 

The recommended Izervay dose is a 2 mg intravitreal injection given once monthly (28 ± 7 days.) for 12 months. 

Izervay is available as a 2 mg (0.1 mL of 20 mg/mL) solution in a single-dose vial.

Prior to use, allow Izervay to reach room temperature, 20⁰C to 25⁰C (68⁰F to 77⁰F). 

You should not use Izervay if you have ocular or periocular infections, or active intraocular inflammation.

Make an appointment or call your qualified physician as soon as you realize you have missed your dose to organize a new appointment,

You may experience temporary visual disturbances and blurring after having your injection and the associated eye examinations. Avoid driving or using machinery until the visual function has recovered sufficiently.

Do not use this medicine if you are allergic to the active ingredient avacincaptad pegol, or other ingredients contained in this medicine; click here for a full list of Izervay ingredients.

The most common Izervay side effects include:

• conjunctival hemorrhage (13%), 
• increased intraocular pressure (9%), 
• blurred vision (8%), 
• neovascular age-related macular degeneration (7%).

Serious Izervay side effects include:

• ocular and periocular infections, 
• Increased elevated intraocular inflammation (IOP), 
• endophthalmitis and retinal detachments, 
• neovascular AMD, 
• increase in intraocular pressure.

This is not a complete list of side effects, and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before using this medicine

You should not use Izervay if you have ocular or periocular infections, or active intraocular inflammation.

Dosing information

Izervay is given by a qualified physician as an intravitreal injection; this is when medication is injected directly into the vitreous humor in the eye. 

The recommended Izervay dose is a 2 mg intravitreal injection given once monthly (28 ± 7 days.) for 12 months. 

Izervay is available as a 2 mg (0.1 mL of 20 mg/mL) solution in a single-dose vial.

Prior to use, allow Izervay to reach room temperature, 20⁰C to 25⁰C (68⁰F to 77⁰F).