Juvederm is a family of injectable hyaluronic acid dermal fillers used to provide 9 months to one year of correction for moderate to severe facial wrinkles and folds, such as nasolabial folds (lines from the nose to the corners of the mouth). It is also used for lip augmentation.

Juvederm products are a smooth consistency gel, compared to some hyaluronic gel products that have a granular consistency. Juvederm products are developed using the Hylacross technology to allow a smoother, malleable gel. Hyaluronic acid is a naturally occurring sugar found in the body. Hyaluronic acid works by holding in water at the injection site and acting as a cushioning agent. It adds temporary volume and a smoother appearance to skin. Most patients need more than one treatment to achieve optimal results.

Juvederm XC products also contain the local anesthetic lidocaine for a more comfortable injection as this numbs the treatment area within seconds. The Juvederm Ultra XC products contain more highly cross-linked formulations for volumizing and correction of deeper folds and wrinkles.

The Juvederm range of products are designed to meet specific needs depending on the area of the face being treated and increase in volume required.

• Juvederm Voluma® XC is used for deep injection in the cheek area to correct age-related volume loss and for augmentation of the chin region to improve the chin profile.
• Juvederm Vollure™ XC is used for injection into the facial tissue for the correction of moderate to severe facial wrinkles and folds, such as nasolabial folds.
• Juvederm ® Ultra Plus XC is used for injection into the facial tissue for the correction of moderate to severe facial wrinkles and folds, such as nasolabial folds.
• Juvederm® Ultra XC is is used for injection into the facial tissue for the correction of moderate to severe facial wrinkles and folds, such as nasolabial folds. It is also used for injection into the lips and perioral area for lip augmentation.
• Juvederm® XC Is suitable for moderate or severe facial folds or wrinkles such as the fold that runs from your nose to mouth (parentheses lines).
• Juvederm Volbella® XC is used for injection into the lips for lip augmentation and correction of perioral lines, and for injection into the undereye hollows to improve the appearance of undereye hollows.
• Juvederm Volux XC injectable gel is used for deep injection to improve moderate to severe loss of jawline definition in adults over the age of 21.

Contraindications: Juvederm injectable gel should not be used in patients who have severe allergies marked by a history of anaphylaxis or a history or presence of multiple severe allergies. Juvederm should not be used in patients with a history of allergies to Gram-positive bacterial proteins. Juvederm Ultra XC and Juvederm Ultra Plus XC should not be used in patients with a history of allergies to lidocaine.

Warnings: Juvederm injectable gel should not be injected into blood vessels as this can cause blood vessel blockage which may result in skin tissue dying, vision impairment (temporary or permanent), and even stroke. If there is an active inflammatory process or infection at specific injection sites, treatment should be deferred until the underlying process is controlled.

Precautions: Juvederm should only be administered under the supervision of a licensed health care practitioner.

• Patients should inform their physician if they are using substances that may prolong bleeding or bruising, such as aspirin, or ibuprofen, or naproxen.
• Inflammation may occur at the treatment site if laser treatment, chemical peeling, or any other dermal procedure is performed after Juvederm treatment.
• Use with caution in patients on immunosuppressive therapy due to the possibility of increased infection risk.
• Safety for use during pregnancy, in breastfeeding, or in patients under 18 years has not been established.
• Safety in patients with excessive scarring (e.g., hypertrophic scarring or keloid formation) and pigmentation disorders has not been studied.

How painful are Juvederm injections?

There may be some discomfort during and after the injection. Juvederm is injected directly into the skin with a fine needle. Juvederm products contain the local anesthetic lidocaine to help lessen discomfort during injection, or the physician may choose to numb the site prior to injection. You should discuss these options with your physician prior to the procedure.

What is expected after the procedure?

Within the first 24 hours, avoid:

• strenuous exercise
• extensive sun or heat exposure
• alcoholic beverages

Exposure to any of the above may lead to temporary redness, swelling, and/or itching at the injection site. If swelling occurs, place an ice pack over the swollen area. Ask the physician how long to wait until make-up can be re-applied after the procedure.

How long does the Juvederm correction last?

Correction with Juvederm is temporary. Re-injections may be needed, typically between 9 months and one year after the initial injection. Smaller injections (about half the amount) are needed for repeat procedures.

What other treatments are available for correction of facial wrinkles and folds?

• Bovine-based collagen
• Other hyaluronic acid-based dermal fillers
• Facial Creams
• Botox (botulinum toxin type A)
• Chemical peels
• Laser skin surface treatments