Perlane is an FDA-approved dermal filler for implantation into the skin for the correction of moderate to severe facial folds and wrinkles, such as nasolabial folds. Perlane is generated by a Streptococcus species of bacteria.

Perlane differs from Restylane primarily in the size of the particles and the depth of the required injection. Perlane, used for deeper wrinkles, has larger particles that are injected deeper into the skin than Restylane. Perlane is not approved for use in lip enhancement, but Restylane can be used for this purpose in patients 21 years of age and older. Clinical studies showed no significant differences in the safety of Restylane and Perlane.

Perlane is comprised of biotechnologically engineered, non-immunogenic, stabilized hyaluronic acid gel particles. Hyaluronic acid is a natural substance found in all living organisms and provides volume and fullness to the skin. The three-dimensional gel particles in Perlane are hydrophilic molecules, attracting and binding to water molecules as they degrade, helping to maintain volume augmentation for about six months.

Perlane should only be administered under the supervision of a licensed practitioner.