Latanoprostene bunod lowers pressure inside the eye by increasing the amount of fluid that drains from the eye.

Latanoprostene bunod ophthalmic (for the eyes) is used to treat open-angle glaucoma or other causes of high pressure inside the eye.

Latanoprostene bunod ophthalmic may also be used for purposes not listed in this medication guide.

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

The usual dose of this medicine is 1 drop into the affected eye every evening. Follow your doctor's dosing instructions very carefully.

Do not use this medicine while wearing contact lenses. Latanoprostene bunod ophthalmic may contain a preservative that can discolor soft contact lenses. Wait at least 15 minutes after using this medicine before putting in your contact lenses.

Wash your hands before using the eye drops.

To apply the eye drops:

• Tilt your head back slightly and pull down your lower eyelid to create a small pocket. Hold the dropper above the eye with the tip down. Look up and away from the dropper and squeeze out a drop.

• Close your eyes for 2 or 3 minutes with your head tipped down, without blinking or squinting. Gently press your finger to the inside corner of the eye for about 1 minute, to keep the liquid from draining into your tear duct.

• Wait at least 5 minutes before using any other eye drops your doctor has prescribed.

Do not touch the tip of the eye dropper or place it directly on your eye. A contaminated dropper can infect your eye, which could lead to serious vision problems.

Do not use the eye drops if the liquid has changed colors or has particles in it. Call your pharmacist for new medicine.

Tell your doctor right away if you have an eye injury or eye infection, or if you plan to have eye surgery.

Store an unopened bottle of the eye drops in a refrigerator. Do not freeze.

After your first use, store the eye drops at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use. Throw away the medicine after 8 weeks have passed since you first opened the bottle.

Usual Adult Dose for Intraocular Hypertension:

Instill 1 drop in the conjunctival sac of the affected eye(s) once a day in the evening

Use: For the reduction of intraocular pressure in patients with open-angle glaucoma or ocular hypertension

Usual Adult Dose for Glaucoma (Open Angle):

Instill 1 drop in the conjunctival sac of the affected eye(s) once a day in the evening

Use: For the reduction of intraocular pressure in patients with open-angle glaucoma or ocular hypertension

Usual Pediatric Dose for Intraocular Hypertension:

17 years or older: Instill 1 drop in the conjunctival sac of the affected eye(s) once a day in the evening

Comments:
-Use in patients 16 years and younger is not recommended due to potential safety concerns related to increased pigmentation following long-term chronic use.

Use: For the reduction of intraocular pressure in patients with open-angle glaucoma or ocular hypertension

Usual Pediatric Dose for Glaucoma (Open Angle):

17 years or older: Instill 1 drop in the conjunctival sac of the affected eye(s) once a day in the evening

Comments:
-Use in patients 16 years and younger is not recommended due to potential safety concerns related to increased pigmentation following long-term chronic use.

Use: For the reduction of intraocular pressure in patients with open-angle glaucoma or ocular hypertension

You should not use latanoprostene bunod ophthalmic if you are allergic to it.

To make sure latanoprostene bunod ophthalmic is safe for you, tell your doctor if you have ever had:

• swelling or an infection in your eye;

• retinal detachment; or

• eye surgery or injury affecting the lens of your eye.

Latanoprostene bunod ophthalmic may cause a gradual change in the color of your eyes or eyelids and lashes, usually an increase in brown pigment. You may also notice increased growth or thickness of your eyelashes. These changes occur slowly and you may not notice them for months or years. Color changes may be permanent even after your treatment ends, and may occur only in the eye being treated. This could result in a cosmetic difference in eye or eyelash color from one eye to the other.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether latanoprostene bunod ophthalmic passes into breast milk or if it could affect the nursing baby. Tell your doctor if you are breast-feeding.

Latanoprostene bunod ophthalmic is not approved for use by anyone younger than 16 years old.

Skip the missed dose and take the next regularly scheduled dose. Do not use extra medicine to make up the missed dose.

An overdose of latanoprostene bunod ophthalmic is not expected to be dangerous. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medication.

Keep this medication in the container it came in, tightly closed, and out of reach of children. Unopened bottles of latanoprostene bunod ophthalmic should be stored in the refrigerator. Do not freeze. After opening, the medication may be stored at room temperature for up to 8 weeks. Store latanoprostene bunod ophthalmic away from light, excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

Unless your doctor tells you otherwise, continue your normal diet.

Avoid using too much of latanoprostene bunod ophthalmic, which can actually make it less effective in lowering the pressure inside the eye.

Do not use other eye medications unless your doctor tells you to.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Latanoprost may cause serious side effects. Stop using latanoprost and call your doctor at once if you have:

• eye swelling, redness, severe discomfort, crusting or drainage (may be signs of infection);

• red, swollen, or itchy eyelids;

• sudden vision changes; or

• severe pain, burning, stinging, or irritation after using latanoprostene bunod ophthalmic.

Common side effects of latanoprostene bunod ophthalmic may include:

• puffy eyelids;

• mild pain or irritation after using the medicine;

• blurred vision; or

• feeling like something is in your eye.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

It is not likely that other drugs you take orally or inject will have an effect on latanoprost used in the eyes. But many drugs can interact with each other. Tell each of your healthcare providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.

Keep all appointments with your doctor.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.