Lokelma is used to treat hyperkalemia (high levels of potassium in the blood) in adults.

Lokelma works directly in the intestines and is not absorbed into your bloodstream.

Lokelma may also be used for purposes not listed in this medication guide.

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

You will need medical tests to help your doctor determine how long to treat you with Lokelma.

Store at room temperature away from moisture and heat.

Lokelma can make it harder for your body to absorb other medicines you take by mouth. If you take any other medicines, take them 2 hours before or 2 hours after you take this medicine.

Tell your doctor if you have ever had:

• slow digestion;

• a bowel obstruction or severe constipation;

• heart problems; or

• if you are on a low-salt diet.

Because Lokelma is not absorbed into the bloodstream, it is not expected to be harmful during pregnancy or while nursing a baby. Tell your doctor if you are pregnant or breast-feeding.

Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Lokelma contains sodium and may cause swelling or rapid weight gain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Other drugs may affect Lokelma, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.