Lomustine is used to treat brain tumors in people who have already received surgery or radiation.

Lomustine is also used with other cancer medicines to treat Hodgkin's disease, after other treatments have failed.

Lomustine may also be used for purposes not listed in this medication guide.

Lomustine can weaken (suppress) your immune system. Serious and sometimes fatal infections may occur up to 6 weeks after you are treated with lomustine. Call your doctor if you have easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), or signs of infection (fever, chills, body aches).

Lomustine can have long lasting effects on your body. Your blood will need to be tested once per week for at least 6 weeks after each dose of this medicine.

Lomustine comes as a capsule to take by mouth. It is usually taken once every 6 weeks on an empty stomach. Your full dose may contain two or more different types and colors of capsules. You will receive only enough capsules for one dose. Take all of the capsules given to you in the prescription bottle at the same time. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take lomustine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

You should wear rubber or latex gloves when you handle the capsules so that your skin does not come into contact with the capsules. If the capsule contents touch your skin, wash the area well with soap and water right away.

Swallow the capsules whole; do not split, chew, or crush them.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Lomustine is taken in a single dose once every 6 weeks. Follow your doctor's dosing instructions very carefully.

Because an overdose of lomustine can be fatal, you will be given only enough of lomustine to take one dose every 6 weeks. To get the correct dose, you may need to take 2 or more capsules that are different types and colors.

Wear disposable rubber gloves when you handle a lomustine capsule. Throw the gloves away after one use.

Do not open the lomustine capsule. Do not use a broken pill. The medicine from a broken pill can be dangerous if it gets on your skin. If this occurs, wash with soap and water. Ask your doctor or pharmacist how to safely handle and dispose of a broken capsule.

Lomustine can weaken (suppress) your immune system. Serious and sometimes fatal infections may occur up to 6 weeks after you are treated with this medicine. You will need frequent medical tests.

Store at room temperature away from heat and moisture. Keep the bottle tightly closed until you are ready to take the medicine.

Lomustine can have long lasting effects on your body. Your blood will need to be tested for at least 6 weeks after each dose of this medicine.

Tell your doctor if you have ever had:

• bone marrow suppression;

• liver disease;

• kidney disease; or

• lung disease or breathing problems.

Using lomustine may increase your risk of developing other types of cancer, such as leukemia. Ask your doctor about your specific risk.

Lomustine can harm an unborn baby if the mother or the father is using this medicine.

• If you are a woman, do not use lomustine if you are pregnant. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 2 weeks after your last dose.

• If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3.5 months (14 weeks) after your last dose.

• Tell your doctor right away if a pregnancy occurs while either the mother or the father is using lomustine.

This medicine may affect fertility (ability to have children) in both men and women. However, it is important to use birth control to prevent pregnancy because lomustine can harm an unborn baby.

Do not breastfeed while using this medicine, and for at least 2 weeks after your last dose.

Call your doctor for instructions if you miss a dose of lomustine.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of lomustine can be fatal.

Overdose can cause stomach pain, vomiting, diarrhea, loss of appetite, dizziness, cough, shortness of breath, signs of infection, or liver problems.

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unless your doctor tells you otherwise, continue your normal diet.

Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Lomustine may cause serious side effects. Call your doctor at once if you have:

• jaundice (yellowing of the skin or eyes);

• easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;

• kidney problems--little or no urination, swelling in your feet or ankles, feeling tired or short of breath;

• signs of infection--fever, chills, sore throat, blisters or ulcers in your mouth, red or swollen gums, trouble swallowing; or

• late-onset lung damage--new or worsening cough, chest pain, shortness of breath (may develop as long as 6 months or later after you take lomustine).

Common side effects of lomustine may include:

• nausea, vomiting;

• delayed infection;

• mouth sores; or

• hair loss.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Other drugs may affect lomustine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.