Netarsudil lowers pressure inside the eye by increasing the amount of fluid that drains from the eye.

Netarsudil ophthalmic (for the eyes) is used to treat open-angle glaucoma or other causes of high pressure inside the eye.

Netarsudil ophthalmic may also be used for purposes not listed in this medication guide.

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Do not use this medicine while wearing soft contact lenses. A preservative in the medicine could discolor the lenses. Use the medicine at least 15 minutes before inserting your contact lenses.

Wash your hands before using the eye drops.

To apply the eye drops:

• Tilt your head back slightly and pull down your lower eyelid to create a small pocket. Hold the dropper above the eye with the tip down. Look up and away from the dropper and squeeze out a drop.

• Close your eyes for 2 or 3 minutes with your head tipped down, without blinking or squinting. Gently press your finger to the inside corner of the eye for about 1 minute, to keep the liquid from draining into your tear duct.

• Use only the number of drops your doctor has prescribed.

• Wait at least 5 minutes before using any other eye drops your doctor has prescribed.

Do not touch the tip of the eye dropper or place it directly on your eye. A contaminated dropper can infect your eye, which could lead to serious vision problems.

Do not use the eye drops if the liquid has changed colors or has particles in it. Call your pharmacist for new medicine.

Store an unopened bottle of eye drops in the refrigerator, do not freeze.

After you start using the eye drops, store them at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

Throw away any unused eye drops after 6 weeks.

Usual Adult Dose for Intraocular Hypertension:

Instill 1 drop in the affected eye(s) once a day in the evening

Use: For the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension

Usual Adult Dose for Glaucoma (Open Angle):

Instill 1 drop in the affected eye(s) once a day in the evening

Use: For the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension

You should not use netarsudil ophthalmic if you are allergic to it

Tell your doctor if you have ever had:

• damage to the surface of your eye (also called the cornea).

It is not known whether netarsudil ophthalmic will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk.

Netarsudil ophthalmic is not approved for use by anyone younger than 18 years old.

Skip the missed dose and use your next dose at the regular time. Do not use two doses at one time.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Keep this medication in the bottle it came in, tightly closed, and out of reach of children. Store unopened bottles in the refrigerator. Opened bottles can be stored in the refrigerator or at room temperature (up to 77°F [25°C]). Dispose of the bottle 6 weeks after opening, even if there is some solution left in the bottle.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

Unless your doctor tells you otherwise, continue your normal diet.

Do not use other eye medications unless your doctor tells you to.

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Netarsudil ophthalmic may cause serious side effects. Call your doctor at once if you have:

• severe eye pain, redness, or irritation.

Common side effects of netarsudil ophthalmic may include:

• eye redness;

• blurred vision; or

• pain after using the eyedrops.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Keep all appointments with your doctor.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.