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Home > Drugs > Digestive enzymes > Pancreaze
Digestive enzymes

Pancreaze

https://themeditary.com/drug/pancreaze-2695.html
Medically Reviewed by Oluni Odunlami, MD TheMediTary.Com | Reviewed: Jul 13, 2023  Additional Content by TheMediTary.Com

Generic name: pancrelipase

Drug class: Digestive enzymes

Dosage form: capsule, delayed release

Availability: Prescription only

Pregnancy & Lactation: Risk data available

Brand names: Zenpep, Creon, Pertzye, Ultresa, Viokace

Contents
Uses Warnings Before Taking Dosage Side effects Interactions
  • Pancreaze (Pancrelipase)-MT 4 McNEIL-17,500 USP units amylase; 4,200 USP units lipase; 10,000 USP units protease-Yellow / Clear-Capsule-shape Pancreaze 17,500 USP units amylase; 4,200 USP units lipase; 10,000 USP units protease (MT 4 McNEIL)
  • Pancreaze (Pancrelipase)-MT 10 McNEIL-43,750 USP units amylase; 10,500 USP units lipase; 25,000 USP units protease-Clear / Pink-Capsule-shape Pancreaze 43,750 USP units amylase; 10,500 USP units lipase; 25,000 USP units protease (MT 10 McNEIL)
  • Pancreaze (Pancrelipase)-MT 16 McNEIL-70,000 USP units amylase; 16,800 USP units lipase; 40,000 USP units protease-Peach / Clear-Capsule-shape Pancreaze 70,000 USP units amylase; 16,800 USP units lipase; 40,000 USP units protease (MT 16 McNEIL)
  • Pancreaze (Pancrelipase)-MT 20 McNEIL-61,000 USP units amylase; 21,000 USP units lipase; 37,000 USP units protease-White-Capsule-shape Pancreaze 61,000 USP units amylase; 21,000 USP units lipase; 37,000 USP units protease (MT 20 McNEIL)
  • View all images

What is Pancreaze?

Pancreaze is a prescription medicine used to treat people who cannot digest food normally because their pancreas does not make enough enzymes due to cystic fibrosis or other conditions. Pancreaze may help your body use fats, proteins, and sugars from food.

Pancreaze contains a mixture of digestive enzymes including lipases, proteases, and amylases from pig pancreas.

Pancreaze is safe and effective in children when taken as prescribed by your doctor.

Warnings

Pancreaze may increase your chance of having a rare bowel disorder called fibrosing colonopathy. This condition is serious and may require surgery. The risk of having this condition may be reduced by following the dosing instructions that your doctor gave you. Call your doctor right away if you have any unusual or severe:

  • stomach area (abdominal) pain
  • bloating
  • trouble passing stool (having bowel movements)
  • nausea, vomiting, or diarrhea

Take Pancreaze exactly as prescribed by your doctor. Do not take more or less Pancreaze than directed by your doctor.

How should I use Pancreaze

Take Pancreaze exactly as your doctor tells you.

  • Do not take more capsules in a day than the number your doctor tells you to take (total daily dose).
  • Always take Pancreaze with a meal or snack and plenty of fluid. If you eat a lot of meals or snacks in a day, be careful not to go over your total daily dose.
  • Your doctor may change your dose based on the amount of fatty foods you eat or based on your weight.
  • Do not crush or chew the Pancreaze capsules or their contents, and do not hold the capsule or contents in your mouth. Crushing, chewing or holding the Pancreaze Capsules in your mouth may cause irritation in your mouth or change the way Pancreaze works in your body.

Giving Pancreaze to infants (children up to 12 months):

  1. Give Pancreaze right before each feeding of formula or breast milk.
  2. Do not mix Pancreaze capsule contents directly into formula or breast milk.
  3. Open the capsules and sprinkle the contents directly into your infant's mouth or mix the contents in a small amount of soft food such as applesauce. These foods should be the kind found in baby food jars that you buy at the store, or other food recommended by your doctor.
  4. If you sprinkle the Pancreaze on food, give the Pancreaze and food mixture to your child right away. Do not store Pancreaze that is mixed with food.
  5. Give your child enough liquid to completely swallow the Pancreaze contents or the Pancreaze and food mixture.
  6. Look into your child’s mouth to make sure that all of the medicine has been swallowed.

Giving Pancreaze to children and adults:

  1. Swallow Pancreaze capsules whole and take them with enough liquid to swallow them right away.
  2. If you have trouble swallowing capsules, open the capsules and sprinkle the contents on a small amount of acidic food such as applesauce. Ask your doctor about other foods you can mix with Pancreaze.
  3. If you sprinkle Pancreaze on food, swallow it right after you mix it and drink plenty of water or juice to make sure the medicine is swallowed completely. Do not store Pancreaze that is mixed with food.
  4. If you forget to take Pancreaze, call your healthcare provider or wait until your next meal and take your usual number of capsules. Take your next dose at your usual time. Do not make up for missed doses.
Detailed Pancreaze dosage information
Pancreaze Dosage information (more detail)

Before Taking

Before taking Pancreaze, tell your doctor about all your medical conditions, including if you:

  • are allergic to pork (pig) products.
  • have a history of blockage of your intestines, or scarring or thickening of your bowel wall (fibrosing colonopathy)
  • have gout, kidney disease, or high blood uric acid (hyperuricemia)
  • have trouble swallowing capsules
  • have any other medical condition
  • are pregnant or plan to become pregnant. It is not known if Pancreaze will harm your unborn baby.
  • are breast-feeding or plan to breast-feed. It is not known if Pancreaze passes into your breast milk. You and your doctor should decide if you will take Pancreaze or breast-feed.

Tell your doctor about all the medicines you take, including prescription and nonprescription medicines, vitamins, or herbal supplements. Know the medicines you take. Keep a list of them and show it to your doctor and pharmacist when you get a new medicine.

Pancreaze pregnancy and breastfeeding warnings (more detail)

Pancreaze side effects

Pancreaze may cause serious side effects, including:

  • See "What is the most important information I should know about Pancreaze?"
  • Irritation of the inside of your mouth. This can happen if Pancreaze is not swallowed completely.
  • Increase in blood uric acid levels. This may cause worsening of swollen, painful joints (gout) caused by an increase in your blood uric acid levels
  • Allergic reactions including trouble with breathing, skin rashes, or swollen lips.

Call your doctor right away if you have any of these symptoms. The most common side effects of Pancreaze include:

  • Pain in your stomach (abdominal area)
  • Gas

Other Possible Side Effects

Pancreaze and other pancreatic enzyme products are made from the pancreas of pigs, the same pigs people eat as pork. These pigs may carry viruses. Although it has never been reported, it may be possible for a person to get a viral infection from taking pancreatic enzyme products that come from pigs.

Tell your doctor if you have any side effect that bothers you or does not go away.

These are not all the possible side effects of Pancreaze. For more information, ask your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

You may also report side effects to McNeil Pediatrics at 1-800-526-7736.

See more: Pancreaze Side Effects

More about Pancreaze (Pancrelipase)

Dosage information
Pancreaze Side Effects
During pregnancy
Pancreaze Prescribing Information
Drug images
Side effects
Drug class: Digestive enzymes

Related treatment guides

Pancreatic Exocrine Dysfunction
Cystic Fibrosis
Chronic Pancreatitis
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Contents
Uses Warnings Before Taking Dosage Side effects Interactions
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