By using this site, you agree to the Privacy Policy and Terms of Use.
Accept
Medical Information, Documents, News - TheMediTary.Com Logo Medical Information, Documents, News - TheMediTary.Com Logo

TheMediTary.Com

Medical Information, Documents, News - TheMediTary.Com

  • Home
  • News
  • Drugs
  • Drugs A-Z
  • Medical Answers
  • About Us
  • Contact
Medical Information, Documents, News - TheMediTary.Com Logo Medical Information, Documents, News - TheMediTary.Com Logo
Search Drugs
  • Drugs
    • Latest Drugs
    • Drugs A-Z
    • Medical Answers
  • News
    • FDA Alerts
    • Medical News
    • Health
    • Consumer Updates
    • Children's Health
  • More TheMediTary.Com
    • About Us
    • Contact
Follow US
Home > Drugs > Antimetabolites > Pralatrexate
Antimetabolites

Pralatrexate

https://themeditary.com/drug/pralatrexate-5372.html
Medically Reviewed by Glamora Samuels, MD TheMediTary.Com | Reviewed: Aug 12, 2023  Additional Content by TheMediTary.Com

Generic name: pralatrexate [ pral-a-trex-ate ]

Drug class: Antimetabolites

Dosage form: intravenous solution (20 mg/ml)

Availability: Prescription only

Pregnancy & Lactation: Risk data available

Brand names: Folotyn

Contents
Uses Warnings Before Taking Dosage Side effects Interactions

What is Pralatrexate?

Pralatrexate is used to treat T-cell lymphoma that has spread throughout the body.

Pralatrexate is usually given after other treatments have failed.

Pralatrexate may also be used for purposes not listed in this medication guide.

Warnings

Pralatrexate can increase your risk of bleeding or infection. Call your doctor if you have unusual bruising or bleeding, or new signs of infection (fever, chills, body aches).

How should I take Pralatrexate

Pralatrexate is given as an infusion into a vein. A healthcare provider will give you this injection.

Pralatrexate is usually given once per week for up to 6 weeks at a time.

Your doctor may have you take folic acid supplements before, during, and after your treatment with pralatrexate. You may also receive vitamin B12 injections every 8 to 10 weeks. This can help protect your blood cells from certain side effects of pralatrexate.

Follow your doctor's dosing instructions very carefully.

Pralatrexate can increase your risk of bleeding or infection. You will need frequent medical tests. Your cancer treatments may be delayed based on the results.

Dosing information

Usual Adult Dose for Lymphoma:

Usual Adult Dose: 30 mg/m2 via intravenous push over 3 to 5 minutes once weekly for 6 weeks in 7 week cycles.

Duration: Until disease progression or unacceptable toxicity.

Comments:
-Patients should take low dose (1 mg to 1.25 mg) oral folic acid daily.
-Folic acid should start 10 days before the first dose of pralatrexate and continue for 30 days after the last dose.
-Patients should also receive a B12 (1 mg) injection within 10 weeks before the first dose of pralatrexate and every 8 to 10 weeks thereafter.
-Subsequent B12 injections may be given the same day as treatment with pralatrexate.

Use: The treatment of patients with relapsed or refractory peripheral T-cell lymphoma (PTCL).

Detailed Pralatrexate dosage information
Pralatrexate Dosage information (more detail)

Before Taking

Tell your doctor if you have ever had liver or kidney problems.

You may need to have a negative pregnancy test before starting this treatment.

Pralatrexate can harm an unborn baby if the mother or the father is using pralatrexate.

  • If you are a woman, do not use pralatrexate if you are pregnant. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 6 months after your last dose.

  • If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 3 months after your last dose.

  • Tell your doctor right away if a pregnancy occurs while either the mother or the father is using pralatrexate.

Do not breastfeed while using this medicine, and for at least 1 week after your last dose.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your pralatrexate injection.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using Pralatrexate?

Do not receive a "live" vaccine while using pralatrexate, or you could develop a serious infection. Live vaccines include measles, mumps, rubella (MMR), rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.

Pralatrexate side effects

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Pralatrexate may cause serious side effects. Call your doctor at once if you have:

  • liver problems--loss of appetite, stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

  • signs of tumor cell breakdown--tiredness, weakness, muscle cramps, nausea, vomiting, diarrhea, fast or slow heart rate, tingling in your hands and feet or around your mouth;

  • low white blood cell counts--fever, skin sores, sore throat, cough, trouble breathing;

  • low red blood cells (anemia)--pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet;

  • low potassium level--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling; or

  • dehydration symptoms--feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin.

Common side effects of pralatrexate may include:

  • sores or white patches in or around your mouth, trouble swallowing or talking, dry mouth, bad breath, altered sense of taste;

  • easy bruising, unusual bleeding, purple or red spots under your skin;

  • nausea; or

  • feeling tired.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See more: Pralatrexate Side Effects

What other drugs will affect Pralatrexate?

Tell your doctor about all your other medicines, especially:

  • trimethoprim;

  • sulfamethoxazole;

  • probenecid; or

  • NSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.

This list is not complete. Other drugs may affect pralatrexate, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

More about Pralatrexate (Pralatrexate [ pral-a-trex-ate ])

Dosage information
Pralatrexate Side Effects
During pregnancy
Drug images
Side effects
Drug class: Antimetabolites

Related treatment guides

Non-Hodgkin's Lymphoma
Peripheral T-cell Lymphoma
Lymphoma
Share this Article
Contents
Uses Warnings Before Taking Dosage Side effects Interactions
Related Drugs
Fidanacogene Elaparvovec
Cerave Anti-Itch
Centrum Adult
Crovalimab
Cyltezo Prefilled Syringe
Zepbound Pen
Mylanta One
Uretron Ds
Medihoney Wound And Burn Dressing
Lidotrode

Other drugs

Name Drug Class Updated
Fidanacogene Elaparvovec Drugs 03-Oct-2024
Cerave Anti-Itch Drugs 02-Oct-2024
Centrum Adult Drugs 02-Oct-2024
Crovalimab Drugs 02-Oct-2024
Cyltezo Prefilled Syringe Drugs 01-Oct-2024
Zepbound Pen Drugs 30-Sep-2024
Mylanta One Drugs 27-Sep-2024
Uretron Ds Drugs 27-Sep-2024
Medihoney Wound And Burn Dressing Drugs 26-Sep-2024
Lidotrode Drugs 26-Sep-2024
Libervant Drugs 26-Sep-2024
Moderna Covid-19 Drugs 25-Sep-2024
Beqvez Drugs 24-Sep-2024
Beqvez Drugs 24-Sep-2024
Beqvez Drugs 24-Sep-2024

Categories

  • FDA Alerts
  • Medical News
  • Health
  • Consumer Updates
  • Children's Health

About US

Welcome to TheMediTary.Com

Our website provides reliable and up-to-date information on various medical topics. We empower individuals to take charge of their health by simplifying complex medical jargon and providing practical tips and advice. We prioritize the privacy and confidentiality of our users and welcome feedback to improve our services.

Website use data of FDA and other sources

DMCA.com Protection Status Truste Protection Status Trust Mark Protection Status
HONcode logo We comply with the HONcode standard for trustworthy health information.
Quick Link
  • About Us
  • Contact Us
  • Editorial Policy
  • Privacy Policy
  • Accessibility Policy
  • Terms & Conditions
  • Disclaimer
  • DMCA
  • Do Not Sell My Personal Information
  • Sitemap
  • Care Notes
  • Health Guide
  • Professional
Drugs
  • New Drugs
  • Medical Answers
  • Drugs A-Z
  • Drug Classes
  • Drug Dosage
  • Pill Identifier
  • Consumer Infor
  • Side Effects
  • Inactive Ingredients
  • Pregnancy Warnings
  • Patient Tips
  • Treatments
News
  • Latest News
  • FDA Alerts
  • Medical News
  • Health
  • Consumer Updates
  • Children's Health
Find US
  • Medium
  • Google Site
  • Blogspot
  • API
  • Reddit
  • Tumblr
  • Scoop.it
  • Substack
  • Wordpress
  • Wix
  • Behance

© 2025 TheMediTary.Com All rights reserved. Operated by