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Home > Drugs > Cholinesterase inhibitors > Razadyne
Cholinesterase inhibitors

Razadyne

https://themeditary.com/drug/razadyne-2924.html
Medically Reviewed by Melisa Puckey, BPharm TheMediTary.Com | Reviewed: Jul 14, 2023  Additional Content by TheMediTary.Com

Generic name: galantamine [ ga-lan-ta-meen ]

Drug class: Cholinesterase inhibitors

Dosage form: tablet

Availability: Prescription only

Pregnancy & Lactation: Risk data available

Brand names: Galantamine

Contents
Uses Warnings Before Taking Dosage Side effects Interactions
  • Razadyne (Galantamine [ ga-lan-ta-meen ])-JANSSEN G 4-4 mg-White-Round Razadyne 4 mg (JANSSEN G 4)
  • Razadyne (Galantamine [ ga-lan-ta-meen ])-JANSSEN G 8-8 mg-Pink-Round Razadyne 8 mg (JANSSEN G 8)
  • View all images

What is Razadyne?

Razadyne is used to treat mild to moderate Alzheimer's type dementia by improving the function of nerve cells in the brain. Razadyne works by increasing the amount of a natural substance in the brain called  acetylcholine (ah see til KO leen) which is needed for processes of memory, thinking and reasoning.  People with dementia usually have lower levels of this substance,  and by increasing the acetylcholine levels Razadyne may improve the ability to think and remember or slow the loss of these abilities. 

Warnings

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Before taking this medicine

You should not use Razadyne if you are allergic to it, or any of the inactive ingredients contained in the product.

To make sure Razadyne is safe for you, tell your doctor if you have:

  • urination problems;
  • heart disease or a heart rhythm disorder;
  • a history of stomach ulcer or bleeding;
  • seizures or epilepsy;
  • kidney disease;
  • liver disease; or
  • a history of asthma or chronic obstructive pulmonary disease (COPD).

Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant. It is not known whether Razadyne will harm an unborn baby.

Breastfeeding

Tell your doctor if you are breastfeeding or planning to breastfeed. It is not known whether this medicine passes into breast milk or if it could affect the nursing baby. 

Razadyne pregnancy and breastfeeding warnings (more detail)

How should I take Razadyne

Take Razadyne exactly as prescribed by your doctor. Your doctor may occasionally change your dose to make sure you get the best results. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.

Take Razadyne with a full glass of water. Drink 6 to 8 full glasses of water each day to keep from getting dehydrated while taking this medication.

If you need surgery, tell the surgeon ahead of time that you are using Razadyne. You may need to stop using the medicine for a short time.

If you have stopped taking Razadyne for any reason, talk with your doctor before you start taking it again. You may need to restart the medication at a lower dose.

 Razadyne Extended-release capsule 

Razadyne extended-release capsule is usually taken once per day in the morning. Follow your doctor's instructions.

The extended-release capsule works best if you take it with food.

Do not crush, chew, break, or open an extended-release capsule. Swallow it whole.

 Razadyne short-acting tablet or the oral solution (liquid) 

The Razadyne short-acting tablet or the oral solution (liquid) are usually given two times per day, with meals. Follow your doctor's instructions.

Measure liquid medicine with the dosing syringe provided or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.

Dosing information

Usual Adult Dose for Alzheimer's Disease:

Immediate release tablet and oral solution:

Initial dose:

  • 4 mg orally twice a day, preferably with morning and evening meals
  • After a minimum of four weeks, increase to 8 mg twice a day, then after an additional 4 weeks, may increase to 12 mg twice a day.

Maintenance dose:

  • 16 to 24 mg per day given in 2 divided doses.

Maximum dose:

  • 24 mg/day

Extended release capsule:

Initial dose:

  • 8 mg orally once a day, preferably with the morning meal.
  • After 4 weeks, dose should be increased to 16 mg once a day, a further increase to 24 mg once a day may be considered after a minimum of 4 weeks of taking 16 mg/day.

Maintenance dose:

  • 16 to 24 mg orally once a day based on clinical benefit and tolerability.

Maximum dose:

  • 24 mg/day.

Conversion from Immediate-Release (IR) Tablets or Oral Solution to Extended-Release (ER) Capsules:

  • Take the last dose of IR formulation in the evening prior to starting ER capsule; start ER capsule following morning at once a day dosing.
  • Converting from IR to ER should occur at the same total daily dosage.

Comments:

  • During clinical trials, an immediate-release dose of 32 mg per day was found to be less well tolerated and did not increase clinical benefit; dosing at 24 mg/day was not found to provide statistically significant increased clinical benefit from 16 mg/day; however, it might provide additional benefit for some patients.
  • Dose increases should be based upon assessment of clinical benefit and tolerability of the previous dose.
  • If therapy is interrupted for more than 3 days, the patient should be restarted at the lowest dosage and the dosage escalated to current dose.
Detailed Razadyne dosage information
Razadyne Dosage information (more detail)

Before Taking

You should not use Razadyne if you are allergic to it, or any of the inactive ingredients contained in the product.

To make sure Razadyne is safe for you, tell your doctor if you have:

  • urination problems;
  • heart disease or a heart rhythm disorder;
  • a history of stomach ulcer or bleeding;
  • seizures or epilepsy;
  • kidney disease;
  • liver disease; or
  • a history of asthma or chronic obstructive pulmonary disease (COPD).

Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant. It is not known whether Razadyne will harm an unborn baby.

Breastfeeding

Tell your doctor if you are breastfeeding or planning to breastfeed. It is not known whether this medicine passes into breast milk or if it could affect the nursing baby. 

Razadyne pregnancy and breastfeeding warnings (more detail)

Related/similar drugs

donepezil, memantine, Aricept, Namenda, rivastigmine, Exelon

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include severe nausea, vomiting, stomach cramps, muscle weakness or spasm, watery eyes, drooling, increased urination or bowel movements, sweating, slow heart rate, feeling light-headed or fainting, and seizure (convulsions).

What should I avoid while using Razadyne?

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Razadyne side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Razadyne can cause serious skin reactions. Stop using Razadyne and call your doctor at once if you have the first signs of any skin rash, no matter how mild.

Razadyne may cause serious side effects. Call your doctor at once if you have:

  • chest pain, slow heart rate;
  • little or no urinating;
  • blood in your urine;
  • signs of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
  • liver problems--nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • dehydration symptoms--feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin;
  • a light-headed feeling, like you might pass out; or
  • severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Common side effects of Razadyne may include:

  • nausea, vomiting, diarrhea, loss of appetite;
  • headache, dizziness; or
  • weight loss.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See more: Razadyne Side Effects

What other drugs will affect Razadyne?

Tell your doctor about all your current medicines and any you start or stop using, especially:

  • atropine;
  • cold or allergy medicine that contains an antihistamine (Benadryl and others);
  • medicine to treat Parkinson's disease;
  • medicine to treat excess stomach acid, stomach ulcer, motion sickness, or irritable bowel syndrome;
  • bladder or urinary medicines--darifenacin, fesoterodine, oxybutynin, tolterodine, solifenacin;
  • bronchodilators--aclidinium, ipratropium, or tiotropium;

This list is not complete. Other drugs may interact with galantamine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

More about Razadyne (Galantamine [ ga-lan-ta-meen ])

Dosage information
Razadyne Side Effects
During pregnancy
Razadyne Prescribing Information
Drug images
Side effects
Drug class: Cholinesterase inhibitors

Related treatment guides

Alzheimer's Disease
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