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Home > Drugs > EGFR inhibitors > Vandetanib
EGFR inhibitors

Vandetanib

https://themeditary.com/drug/vandetanib-5824.html
Medically Reviewed by Oluni Odunlami, MD TheMediTary.Com | Reviewed: Aug 12, 2023  Additional Content by TheMediTary.Com

Generic name: vandetanib [ van-det-a-nib ]

Drug class: EGFR inhibitors, Multikinase inhibitors, VEGF/VEGFR inhibitors

Dosage form: oral tablet (100 mg; 300 mg)

Availability: Prescription only

Pregnancy & Lactation: Risk data available

Brand names: Caprelsa

Contents
Uses Warnings Before Taking Dosage Side effects Interactions

What is Vandetanib?

Vandetanib is used in adults to treat thyroid cancer.

Vandetanib is available only from a certified pharmacy under a special program.

Vandetanib may also be used for purposes not listed in this medication guide.

Warnings

Vandetanib can cause a serious heart problem, especially if you also use certain other medicines or have certain conditions. You should not use vandetanib if you have long QT syndrome. Tell your doctor about all your current medicines.

You will need medical tests every 2 weeks to 3 months.

Call your doctor right away if you have fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness.

How should I take Vandetanib

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Vandetanib is usually taken once per day, with or without food.

Swallow the tablet whole and do not crush or chew it. Take vandetanib with a full glass of water.

If you cannot swallow a tablet whole, place it into a glass with 2 ounces of plain water. Stir until the tablet is dispersed (it will not dissolve completely). Drink this mixture right away. Add 4 ounces more water to the glass, swirl gently and drink right away.

The dispersed tablet mixture can also be given through a nasogastric (NG) or gastronomy feeding tube. Follow your doctor's instructions.

You will need blood tests and an electrocardiograph or ECG (sometimes called an EKG) every 2 weeks to 3 months. Your dose or medication schedule may be changed based on the results.

If you need surgery, tell your surgeon you currently use this medicine. You may need to stop taking vandetanib for at least 1 month before having surgery. Follow your doctor's instructions about when to start taking the medicine again.

Do not stop taking vandetanib unless your doctor tells you to. If you stop for longer than 2 weeks for any reason, do not start taking vandetanib again without asking your doctor. You may need an ECG before you start taking the medicine again.

Store at room temperature away from moisture and heat.

Dosing information

Usual Adult Dose for Thyroid Cancer:

Initial dose: 300 mg orally once daily.
Duration of therapy: Continue drug until disease progression or unacceptable toxicity occurs.

Use: For the treatment of symptomatic or progressive medullary thyroid cancer in patients with unresectable locally advanced or metastatic disease.

Detailed Vandetanib dosage information
Vandetanib Dosage information (more detail)

Before Taking

You should not use vandetanib if you are allergic to it, or if you have:

  • long QT syndrome.

Tell your doctor if you have ever had:

  • a heart rhythm disorder (in you or a family member);

  • other heart problems, or high blood pressure;

  • low blood levels of calcium, magnesium, or potassium;

  • abnormal thyroid function tests;

  • a seizure;

  • breathing problems, cough with bloody mucus;

  • liver or kidney disease;

  • skin problems; or

  • severe diarrhea.

You may need to have a negative pregnancy test before starting this treatment.

Do not use vandetanib if you are pregnant. It could harm the unborn baby. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 4 months after your last dose. Tell your doctor right away if you become pregnant.

Do not breastfeed while using this medicine, and for at least 4 months after your last dose.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if your next dose is due in less than 12 hours. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I know about storage and disposal of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What should I avoid while using Vandetanib?

Avoid driving or hazardous activity until you know how vandetanib will affect you. Your reactions could be impaired.

Avoid taking an herbal supplement containing St. John's wort at the same time you are taking vandetanib.

Avoid exposure to sunlight or tanning beds. Vandetanib can make you sunburn more easily, for up to 4 months after you stop taking the medicine. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.

Vandetanib side effects

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

You may need to stop taking vandetanib permanently if you have a severe skin reaction.

Vandetanib may cause serious side effects. Call your doctor at once if you have:

  • fast or pounding heartbeats, fluttering in your chest, sudden dizziness (like you might pass out);

  • wheezing, dry cough, feeling short of breath;

  • any wound that will not heal;

  • severe or ongoing diarrhea;

  • unusual bruising or bleeding;

  • cough with bloody mucus, vomit that looks like coffee grounds;

  • swelling, rapid weight gain;

  • headache, confusion, change in mental status, seizure;

  • thyroid symptoms--extreme tiredness, dry skin, joint pain or stiffness, muscle pain or weakness, hoarse voice, feeling more sensitive to cold temperatures, weight gain; or

  • high blood pressure--severe headache, pounding in your neck or ears, anxiety, irregular heartbeats.

Stop using vandetanib and call your doctor at once if you have signs of a stroke:

  • sudden numbness or weakness (especially on one side of the body);

  • confusion, trouble speaking or understanding what is said to you;

  • sudden severe headache; or

  • problems with vision or balance.

Common side effects of vandetanib may include:

  • high blood pressure;

  • diarrhea, stomach pain, nausea, loss of appetite;

  • headache, tiredness;

  • acne, skin rash; or

  • cold symptoms such as stuffy nose, sneezing, sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See more: Vandetanib Side Effects

What other drugs will affect Vandetanib?

Vandetanib can cause a serious heart problem. Your risk may be higher if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV.

Many drugs can affect vandetanib. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

What other information should I know?

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to vandetanib. Your doctor will also check your blood pressure regularly during your treatment with vandetanib.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

More about Vandetanib (Vandetanib [ van-det-a-nib ])

Dosage information
Vandetanib Side Effects
During pregnancy
Drug images
Side effects
Breastfeeding Warnings
Drug class: EGFR inhibitors

Related treatment guides

Thyroid Cancer
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