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Home > Drugs > PI3K inhibitors > Vijoice
PI3K inhibitors

Vijoice

https://themeditary.com/drug/vijoice-3580.html
Medically Reviewed by Judith Stewart, BPharm TheMediTary.Com | Reviewed: Jul 14, 2023  Additional Content by TheMediTary.Com

Generic name: alpelisib

Drug class: PI3K inhibitors

Dosage form: tablets

Availability: Prescription only

Pregnancy & Lactation: Risk data available

Brand names: Piqray, Alpelisib, Alpelisib (monograph), Alpelisib

Contents
Uses Warnings Before Taking Dosage Side effects Interactions

What is Vijoice?

Vijoice is a prescription medicine used to treat adults and children 2 years of age and older with severe phosphatidylinositol-3-kinase catalytic subunit alpha (PIK3CA)-Related Overgrowth Spectrum (PROS).

It is not known if this medicine is safe and effective in children below 2 years of age.

How should I take Vijoice

  • Take Vijoice tablets exactly as your healthcare provider tells you.
  • Do not change your dose or stop treatment unless your healthcare provider tells you.
  • Take Vijoice tablets 1 time each day, at about the same time each day.
  • Take the tablets with food.
  • Swallow the tablets whole. Do not split or chew the tablets.
  • Do not take tablets that are broken, cracked or that look damaged at the time of opening the blister pack.
  • If you cannot swallow tablets whole, you can take them mixed with water (suspension) as follows:
    • Place the tablets into a glass that contains 2 to 4 ounces of water and let it stand for about 5 minutes.
      Use water only.
    • Crush the tablets with a spoon and stir to dissolve. The liquid will be cloudy and you may see tablet pieces.
    • Swallow the mixture right away.
    • Next, add about 2 to 3 tablespoons of water to the same glass and stir with the same spoon. Then swallow the entire contents of the glass to ensure the entire dose is consumed. Repeat this step if necessary.
    • Throw away any of the mixture that is not taken within 60 minutes after it is prepared.
  • If you miss a dose, you may still take it with food up to 9 hours after the time you usually take it. If it has been more than 9 hours after you usually take your dose, skip the dose for that day. The next day, take the dose at your usual time. Do not take 2 doses to make up for a missed dose.
  • If you vomit after taking a dose, do not take another dose on that day. Take your next dose at your usual time.
  • If you take too much or overdose, call your healthcare provider or go to the nearest hospital emergency room right away.

Dosing information

Usual Adult Dosage for PIK3CA-Related Overgrowth Spectrum

- 250 mg taken orally once daily with food.

- Use: treatment of adult patients with severe manifestations of PIK3CARelated Overgrowth Spectrum (PROS) who require systemic therapy.

Usual Pediatric Dosage for PIK3CA-Related Overgrowth Spectrum

- 50 mg taken orally once daily with food.

- Use: treatment of pediatric patients (2 years to less than 18 years of age) with severe manifestations of PIK3CARelated Overgrowth Spectrum (PROS) who require systemic therapy.

Detailed Vijoice dosage information
Vijoice Dosage information (more detail)

Before Taking

You should not take Vijoice if you have had a severe allergic reaction to alpelisib or are allergic to any of the ingredients.

  • See the end of this page for a complete list of the ingredients.
  • See Vijoice side effects for signs and symptoms of severe allergic reactions.
Vijoice pregnancy and breastfeeding warnings (more detail)

Before you take Vijoice

Before you start treatment, tell your healthcare provider about all of your medical conditions, including if you:

  • have a history of diabetes.
  • have a history of skin rash, redness of skin, blistering of the lips, eyes or mouth, or skin peeling.
  • are pregnant or plan to become pregnant. Vijoice can harm your unborn baby.
    Females who are able to become pregnant:
    • Your healthcare provider will check to see if you are pregnant before you start treatment.
    • You should use effective birth control during treatment, and for 1 week after the last dose. Talk to your healthcare provider about birth control methods that may be right for you during this time.
    • If you become pregnant or think you are pregnant, tell your healthcare provider right away.

Males with female partners who are able to become pregnant should use condoms and effective birth control during treatment, and for 1 week after the last dose. If your female partner becomes pregnant, tell your healthcare provider right away.

  • are breastfeeding or plan to breastfeed. It is not known if Vijoice passes into your breast milk. Do not breastfeed during treatment, and for 1 week after the last dose.

Related/similar drugs

Arimidex, Femara, Xeloda, Herceptin, Ibrance, Verzenio, alpelisib

Vijoice side effects

Vijoice may cause serious side effects, including:

  • Severe allergic reactions. Tell your healthcare provider or get medical help right away if you have trouble breathing, flushing, rash, fever, or fast heart rate during treatment.
  • Severe skin reactions. Tell your healthcare provider or get medical help right away if you get severe rash or rash that keeps getting worse, reddened skin, flu-like symptoms, blistering of the lips, eyes or mouth, blisters on the skin or skin peeling, with or without fever.
  • High blood sugar levels (hyperglycemia). Hyperglycemia is common with Vijoice and can be severe. Your healthcare provider will monitor your sugar levels before you start, and during treatment. Your healthcare provider may monitor your sugar levels more often if you have a history of diabetes. Tell your healthcare provider right away if you develop symptoms of hyperglycemia, including:
    • excessive thirst
    • dry mouth
    • more frequent urination than usual or a higher amount of urine than normal
    • increased appetite with weight loss
    • confusion
    • nausea
    • vomiting
    • fruity odor on breath
    • difficulty breathing
    • dry or flushed skin
  • Lung problems (pneumonitis). Tell your healthcare provider right away if you develop new or worsening symptoms of lung problems, including:
    • shortness of breath or trouble breathing
    • cough
    • chest pain
  • Diarrhea. Diarrhea is common with Vijoice and can be severe. Severe diarrhea can lead to the loss of too much body water (dehydration) and kidney injury. Tell your healthcare provider right away if you develop diarrhea during treatment. Your healthcare provider may tell you to drink more fluids or take medicines to treat diarrhea.

Your healthcare provider may tell you to decrease your dose, temporarily stop your treatment, or completely stop your treatment if you get certain serious side effects.

The most common side effects include:

  • diarrhea
  • high blood sugar
  • dry skin
  • mouth sores (stomatitis)
  • headache
  • hair loss (alopecia)

Vijoice may affect fertility in males and in females who are able to become pregnant. Talk to your healthcare provider if this is a concern for you. These are not all of the possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See more: Vijoice Side Effects

What other drugs will affect Vijoice?

Tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Vijoice and other medicines may affect each other causing side effects. Know the medicines you take. Keep a list of them to show your healthcare provider or pharmacist when you get
a new medicine.

More about Vijoice (Alpelisib)

Dosage information
Vijoice Side Effects
During pregnancy
Vijoice Prescribing Information
Drug images
Side effects
Drug class: PI3K inhibitors

Related treatment guides

PIK3CA-Related Overgrowth Spectrum
Breast Cancer
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