By using this site, you agree to the Privacy Policy and Terms of Use.
Accept
Medical Information, Documents, News - TheMediTary.Com Logo Medical Information, Documents, News - TheMediTary.Com Logo

TheMediTary.Com

Medical Information, Documents, News - TheMediTary.Com

  • Home
  • News
  • Drugs
  • Drugs A-Z
  • Medical Answers
  • About Us
  • Contact
Medical Information, Documents, News - TheMediTary.Com Logo Medical Information, Documents, News - TheMediTary.Com Logo
Search Drugs
  • Drugs
    • Latest Drugs
    • Drugs A-Z
    • Medical Answers
  • News
    • FDA Alerts
    • Medical News
    • Health
    • Consumer Updates
    • Children's Health
  • More TheMediTary.Com
    • About Us
    • Contact
Follow US
Home > Drugs > Multikinase inhibitors > Xalkori
Multikinase inhibitors

Xalkori

https://themeditary.com/drug/xalkori-790.html
Medically Reviewed by Judith Stewart, BPharm TheMediTary.Com | Reviewed: Jul 12, 2023  Additional Content by TheMediTary.Com

Generic name: crizotinib [ kriz-oh-ti-nib ]

Drug class: Multikinase inhibitors

Dosage form: capsule

Availability: Prescription only

Pregnancy & Lactation: Risk data available

Brand names: Crizotinib

Contents
Uses Warnings Before Taking Dosage Side effects Interactions FAQ
  • Xalkori (Crizotinib [ kriz-oh-ti-nib ])-Pfizer CRZ 250-250 mg-Pink-Capsule-shape Xalkori 250 mg (Pfizer CRZ 250)
  • Xalkori (Crizotinib [ kriz-oh-ti-nib ])-Pfizer CRZ 200-200 mg-Pink & White-Capsule-shape Xalkori 200 mg (Pfizer CRZ 200)
  • View all images

What is Xalkori?

Xalkori is a cancer medication that interferes with the growth and spread of cancer cells in the body.

Xalkori is used to treat non-small cell lung cancer that has spread to other parts of the body and is caused by a defect in either a gene called ALK (anaplastic lymphoma kinase) or a gene called ROS1. 

Xalkori is used to treat anaplastic large cell lymphoma (ALCL) in young adults and children 1 year of age and older whose cancer is ALK-positive. It is used when the ALCL has returned or when a treatment has been tried and it did not work or is no longer working.

Xalkori is also used to treat ALK-positive inflammatory myofibroblastic tumors (IMT) in adults and pediatric patients 1 year of age and older. It is used when the IMT cannot be surgically removed, or has returned, or when a treatment has been tried and it did not work or is no longer working.

 Xalkori may also be used for purposes not listed in this medication guide.

It is not known if Xalkori is safe and effective in older adults with ALCL or in children younger than 1 year of age with ALCL or IMT. 

Warnings

Xalkori can cause serious heart or liver problems. Call your doctor at once if you have: fast or pounding heartbeats, sudden dizziness, shortness of breath, tiredness, itching, upper stomach pain, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes).

Do not use Xalkori if you are pregnant. It could harm the unborn baby. Use effective birth control while you are using this medicine and for at least 3 months after your treatment ends, whether you are a man or a woman.

Before you take Xalkori, tell your doctor if you have liver or kidney disease, a heart rhythm disorder, an electrolyte imbalance (such as low levels of potassium or magnesium in your blood), or a personal or family history of Long QT syndrome.

How should I take Xalkori

Take Xalkori exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.

Before you start treatment, your doctor may perform tests to make sure Xalkori is the best treatment for your type of lung cancer.

Xalkori is usually taken twice per day, with or without food.

Swallow the capsule whole and do not crush, chew, break, or open it.

You may need frequent medical tests to be sure this medicine is not causing harmful effects. Your cancer treatments may be delayed based on the results.

You should not stop taking Xalkori without your doctor's advice.

Store at room temperature away from moisture and heat.

Dosing information

Usual Adult Dose for Non-Small Cell Lung Cancer:

250 mg orally twice a day

Use: For the treatment of patients with metastatic non-small cell lung cancer (NSCLC) whose tumors are anaplastic lymphoma kinase (ALK) or ROS1-positive as detected by an FDA-approved test

Comments:
-Select patients for the treatment of metastatic NSCLC based on the presence of ALK or ROS1 positivity in tumor specimens.
-Continue treatment until disease progression or unacceptable toxicity.

Usual Pediatric Dose for Lymphoma:

280 mg/m2 orally twice a day

Use: For the treatment of pediatric patients 1 year of age and older and young adults with relapsed or refractory, systemic anaplastic large cell lymphoma (ALCL) that is ALK-positive.

Usual Adult Dose for Inflammatory Myofibroblastic Tumor:

250 mg orally twice a day

Use: For the treatment of adults with unresectable, recurrent, or refractory inflammatory myofibroblastic tumor (IMT) that is ALK-positive.

Usual Pediatric Dose for Inflammatory Myofibroblastic Tumor:

280 mg/m2 orally twice a day

Use: For the treatment of pediatric patients 1 year of age and older with unresectable, recurrent, or refractory inflammatory myofibroblastic tumor (IMT) that is ALK-positive.

Detailed Xalkori dosage information
Xalkori Dosage information (more detail)

Before Taking

You should not use Xalkori if you are allergic to crizotinib.

To make sure Xalkori is safe for you, tell your doctor if you have:

  • liver or kidney disease;

  • a heart rhythm disorder;

  • an electrolyte imbalance (such as low levels of potassium or magnesium in your blood);

  • long QT syndrome (in you or a family member); or

  • if you take any heart or blood pressure medicines.

Crizotinib can harm an unborn baby or cause birth defects if the mother or the father is using this medicine.

You may need to have a negative pregnancy test before starting this treatment.

  • If you are a woman, do not use Xalkori if you are pregnant. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 45 days after your last dose.

  • If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 90 days after your last dose.

  • Tell your doctor right away if a pregnancy occurs while either the mother or the father is using Xalkori.

This medicine may affect fertility (ability to have children) in both men and women. However, it is important to use birth control to prevent pregnancy because crizotinib can harm an unborn baby.

You should not breastfeed while you are taking Xalkori and for at least 45 days after your last dose.

Xalkori pregnancy and breastfeeding warnings (more detail)

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if your next dose is due in less than 6 hours. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using Xalkori?

Grapefruit may interact with crizotinib and lead to unwanted side effects. Avoid the use of grapefruit products.

This medicine may cause blurred vision and may impair your reactions. Avoid driving or hazardous activity until you know how this medicine will affect you.

Crizotinib can pass into body fluids (urine, feces, vomit). Caregivers should wear rubber gloves while cleaning up a patient's body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.

Xalkori side effects

Get emergency medical help if you have signs of an allergic reaction to Xalkori: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • increased sensitivity of your eyes to light, seeing flashes of light or "floaters";

  • blurred vision, double vision, or vision loss;

  • fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out);

  • very slow heartbeats;

  • a light-headed feeling, like you might pass out;

  • sudden chest pain or discomfort, wheezing, dry cough or cough with mucus, feeling short of breath;

  • fever, swollen gums, painful mouth sores, pain when swallowing, cold or flu symptoms;

  • easy bruising or bleeding (nosebleeds, bleeding gums); or

  • liver problems - nausea, upper stomach pain, itching, tiredness, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Common Xalkori side effects may include:

  • nausea, vomiting, decreased appetite;

  • diarrhea, constipation;

  • abnormal liver function tests;

  • swelling in your hands, feet, or eyes;

  • numbness or tingling in your hands or feet;

  • muscle weakness, trouble walking;

  • cold symptoms such as stuffy nose, sneezing, sore throat;

  • dizziness, tiredness; or

  • vision problems.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See more: Xalkori Side Effects

What other drugs will affect Xalkori?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Crizotinib can cause a serious heart problem. Your risk may be higher if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV.

Many drugs can interact with crizotinib. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

Popular FAQ

How long does it take for Xalkori to work?
Do I need any blood tests while taking Xalkori?
Is Xalkori the same as Opdivo or Keytruda?
What cancers are treated with Xalkori?

More about Xalkori (Crizotinib [ kriz-oh-ti-nib ])

Dosage information
Xalkori Side Effects
During pregnancy
Xalkori Prescribing Information
Drug images
Side effects
Drug class: Multikinase inhibitors

Related treatment guides

Inflammatory Myofibroblastic Tumors
Non-Small Cell Lung Cancer
Lymphoma
Share this Article
Contents
Uses Warnings Before Taking Dosage Side effects Interactions FAQ
Related Drugs
Fidanacogene Elaparvovec
Cerave Anti-Itch
Centrum Adult
Crovalimab
Cyltezo Prefilled Syringe
Zepbound Pen
Mylanta One
Uretron Ds
Medihoney Wound And Burn Dressing
Lidotrode

Other drugs

Name Drug Class Updated
Fidanacogene Elaparvovec Drugs 03-Oct-2024
Cerave Anti-Itch Drugs 02-Oct-2024
Centrum Adult Drugs 02-Oct-2024
Crovalimab Drugs 02-Oct-2024
Cyltezo Prefilled Syringe Drugs 01-Oct-2024
Zepbound Pen Drugs 30-Sep-2024
Mylanta One Drugs 27-Sep-2024
Uretron Ds Drugs 27-Sep-2024
Medihoney Wound And Burn Dressing Drugs 26-Sep-2024
Lidotrode Drugs 26-Sep-2024
Libervant Drugs 26-Sep-2024
Moderna Covid-19 Drugs 25-Sep-2024
Beqvez Drugs 24-Sep-2024
Beqvez Drugs 24-Sep-2024
Beqvez Drugs 24-Sep-2024

Categories

  • FDA Alerts
  • Medical News
  • Health
  • Consumer Updates
  • Children's Health

About US

Welcome to TheMediTary.Com

Our website provides reliable and up-to-date information on various medical topics. We empower individuals to take charge of their health by simplifying complex medical jargon and providing practical tips and advice. We prioritize the privacy and confidentiality of our users and welcome feedback to improve our services.

Website use data of FDA and other sources

DMCA.com Protection Status Truste Protection Status Trust Mark Protection Status
HONcode logo We comply with the HONcode standard for trustworthy health information.
Quick Link
  • About Us
  • Contact Us
  • Editorial Policy
  • Privacy Policy
  • Accessibility Policy
  • Terms & Conditions
  • Disclaimer
  • DMCA
  • Do Not Sell My Personal Information
  • Sitemap
  • Care Notes
  • Health Guide
  • Professional
Drugs
  • New Drugs
  • Medical Answers
  • Drugs A-Z
  • Drug Classes
  • Drug Dosage
  • Pill Identifier
  • Consumer Infor
  • Side Effects
  • Inactive Ingredients
  • Pregnancy Warnings
  • Patient Tips
  • Treatments
News
  • Latest News
  • FDA Alerts
  • Medical News
  • Health
  • Consumer Updates
  • Children's Health
Find US
  • Medium
  • Google Site
  • Blogspot
  • API
  • Reddit
  • Tumblr
  • Scoop.it
  • Substack
  • Wordpress
  • Wix
  • Behance

© 2025 TheMediTary.Com All rights reserved. Operated by