Note: This document contains side effect information about famotidine / ibuprofen. Some dosage forms listed on this page may not apply to the brand name Duexis.
Summary
Common side effects of Duexis include: increased serum alanine aminotransferase and increased serum aspartate aminotransferase. Continue reading for a comprehensive list of adverse effects.
Applies to famotidine / ibuprofen: oral tablet.
Warning
Oral route (Tablet)
NSAIDs cause an increased risk of serious cardiovascular thrombotic events, including myocardial infarction and stroke, which can be fatal. This risk may occur early in treatment and may increase with duration of use. Famotidine/ibuprofen is contraindicated in the setting of coronary artery bypass graft surgery. NSAIDs cause an increased risk of serious gastrointestinal (GI) adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients and patients with a prior history of peptic ulcer disease and/or GI bleeding are at greater risk for serious GI events.
Serious side effects of Duexis
Along with its needed effects, famotidine / ibuprofen may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking famotidine / ibuprofen:
Less common
- Bladder pain
- bloating or swelling of the face, arms, hands, lower legs, or feet
- bloody or black, tarry stools
- blurred vision
- chills
- clay-colored stools
- cloudy urine
- constipation
- cough
- dark-colored urine
- diarrhea
- difficult, burning, or painful urination
- dizziness
- fever
- frequent urge to urinate
- general feeling of discomfort or illness
- headache
- heartburn
- indigestion
- itching or rash
- joint pain
- light-colored stools
- loss of appetite
- lower back or side pain
- muscle aches and pains
- nausea
- nervousness
- pale skin
- pounding in the ears
- rapid weight gain
- runny nose
- severe stomach pain
- shivering
- slow or fast heartbeat
- sore throat
- stomach pain, cramping, or burning
- sweating
- tingling of the hands or feet
- trouble sleeping
- trouble breathing
- unpleasant breath odor
- unusual bleeding or bruising
- unusual tiredness or weakness
- unusual weight gain or loss
- vomiting
- vomiting of blood or material that looks like coffee grounds
- yellow eyes or skin
Incidence not known
- Blistering, peeling, or loosening of the skin
- change in consciousness
- confusion as to time, place, or person
- cracks in the skin
- darkening of the skin
- depression
- dry mouth
- fainting
- hallucinations
- holding false beliefs that cannot be changed by fact
- loss of consciousness
- loss of heat from the body
- pain in the lower back or side
- pain in the chest, groin, or legs, especially calves of the legs
- red skin lesions, often with a purple center
- red, irritated eyes
- red, swollen skin
- scaly skin
- seizures
- severe headaches of sudden onset
- sores, ulcers, or white spots in the mouth or on the lips
- stiff neck or back
- sudden loss of coordination
- sudden onset of slurred speech
- sudden vision changes
- swollen glands
- thirst
- unusual excitement, nervousness, or restlessness
Other side effects of Duexis
Some side effects of famotidine / ibuprofen may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common
- Back pain
- belching
- body aches or pain
- cough producing mucus
- difficulty having a bowel movement
- difficulty with moving
- ear congestion
- loss of voice
- muscle stiffness
- pain or tenderness around the eyes and cheekbones
- sneezing
- stuffy nose
For Healthcare Professionals
Applies to famotidine / ibuprofen: oral tablet.
General
Famotidine-Ibuprofen:
The most frequently reported side effects included nausea, diarrhea, constipation, upper abdominal pain, and headache.[Ref]
Gastrointestinal
Famotidine-Ibuprofen:
Common (1% to 10%): Nausea, dyspepsia, diarrhea, constipation, upper abdominal pain, gastroesophageal reflux disease, vomiting, stomach discomfort, abdominal pain
Famotidine:
Postmarketing reports: Nausea, diarrhea, vomiting, abdominal pain
Ibuprofen:
Common (1% to 10%): Nausea, dyspepsia, diarrhea, constipation, upper abdominal pain, gastroesophageal reflux disease, vomiting, stomach discomfort, abdominal pain[Ref]
Cardiovascular
Famotidine-Ibuprofen:
Common (1% to 10%): Hypertension
Famotidine:
Postmarketing reports: Hypotension
Ibuprofen:
Common (1% to 10%): Hypertension
Postmarketing reports: Myocardial infarction[Ref]
Renal
Famotidine-Ibuprofen:
Common (1% to 10%): Serum creatinine increased
Frequency not reported: Acute renal failure
Ibuprofen:
Common (1% to 10%): Serum creatinine increased
Postmarketing reports: Acute renal failure[Ref]
Hematologic
Famotidine-Ibuprofen:
Common (1% to 10%): Anemia
Famotidine:
Postmarketing reports: Anemia, thrombocytopenia, platelet count decreased, hemoglobin decreased
Ibuprofen:
Common (1% to 10%): Anemia[Ref]
Hepatic
Famotidine:
Postmarketing reports: Hepatic function abnormal, ALT increased, AST increased
Other
Famotidine-Ibuprofen:
Common (1% to 10%): Peripheral edema, influenza
Famotidine:
Postmarketing reports: Pyrexia, condition aggravated, asthenia, drug ineffective, chest pain, fatigue, pain, peripheral edema, sepsis
Ibuprofen:
Common (1% to 10%): Peripheral edema, influenza
Postmarketing reports: Pyrexia, pain, fatigue, asthenia, chest pain, drug ineffective[Ref]
Metabolic
Famotidine:
Postmarketing reports: Appetite decreased[Ref]
Musculoskeletal
Famotidine-Ibuprofen:
Common (1% to 10%): Arthralgia, back pain
Ibuprofen:
Common (1% to 10%): Arthralgia, back pain[Ref]
Nervous system
Famotidine-Ibuprofen:
Common (1% to 10%): Headache
Famotidine:
Postmarketing reports: Dizziness, headache
Ibuprofen:
Common (1% to 10%): Headache
Postmarketing reports: Dizziness[Ref]
Respiratory
Famotidine-Ibuprofen:
Common (1% to 10%): Upper respiratory tract infection, nasopharyngitis, sinusitis, bronchitis, cough, pharyngolaryngeal pain
Famotidine:
Postmarketing reports: Pneumonia, dyspnea
Ibuprofen:
Common (1% to 10%): Upper respiratory tract infection, nasopharyngitis, sinusitis, bronchitis, cough, pharyngolaryngeal pain
Postmarketing reports: Dyspnea[Ref]
Genitourinary
Famotidine-Ibuprofen:
Common (1% to 10%): Urinary tract infection
Ibuprofen:
Common (1% to 10%): Urinary tract infection[Ref]
Psychiatric
Ibuprofen:
Postmarketing reports: Depression, anxiety[Ref]
